This is a revision of a renewal application for a project known as the Victoria Longitudinal Study (VLS). A prospective study underway for over 20 years, the VLS has operated effectively and productively for the last decade in two coordinated labs. The general objective of the VLS is to examine actual short- and long-term changes in middle-aged and older adults across many domains of cognition as they are dynamically influenced and modified by multiple aspects of health (e.g., conditions, beliefs), biological attributes (e.g., functional, genetic), lifestyle activities (e.g., cognitive, social, physical engagement), and neuropsychological status (e.g., cognitively successful, normal, cognitively impaired). According to our Research Plan, we collect systematic, multivariate, and comprehensive data on long-term volunteer participants through repeated waves of observation at regular intervals (every 3-4 years, with 10-12 hours of testing at each wave). Since its inception, the VLS follows a design that features three initially healthy sequential samples (all initially aged 55-85 years, now about 63-100+ years). The three samples were begun in adjacent decades (1980s, 1990s, and 2000s). The VLS now has longitudinal data that span a gradient of 40 years of aging, plus numerous control (e.g., younger, middle-aged adults) and emerging target and comparison groups (e.g., Type 2 diabetes, Mild Cognitive Impairment). The current Specific Aims are to (a) continue the systematic assembly of a rich data archive on actual cognitive changes with aging, (b) identify key patterns of cognitive differences, changes, and transitions with aging, and (c) investigate theoretically and clinically relevant precursors, correlates, and modifiers of healthy, normal, and impaired changes with aging. We report substantial progress in pursuing these aims in the recent grant period. Our Proposed Research includes (a) continued collection of critical waves of longitudinal data, (b) development and management of all longitudinal and comparison samples, and (c) new research in four integrative themes of contemporary cognitive aging. Each proposed theme involves innovative studies on (a) independent and interacting influences (e.g., health, lifestyle, genetic, functional across (b) multiple domains of reliably measured cognitive change (e.g., declarative memory, executive function, speed and inconsistency) using (c) well-characterized and large samples of broad age-bands of adults who may be (d) representative of theoretically and clinically interesting health groups of significance to aging, and are always (e) followed carefully across longitudinal waves. The General Significance of the VLS lies in its ever-growing rich, unique, and multi-faceted data set on actual changes in human aging. A more specific significance pertains to the increasingly integrative studies showing both independent and interactive influences on cognitive aging trajectories and outcomes. The research we conduct addresses historically valid and currently compelling empirical, theoretical, and practical issues of health and aging.
Our longitudinal study has adopted an approach to the study of human cognitive aging that involves several integrated features. Our perspective involves studying (a) actual aging with change-sensitive designs and analyses, (b) multiple cognitive processes followed over short- and long-term periods, and (c) independent, interacting, and emerging influences and outcomes from health, biological, environmental, lifestyle, and neuropsychological domains. Our studies provide new theoretical and applied information on healthy, normal, and impaired cognitive aging.
|Sapkota, Shraddha; Wiebe, Sandra A; Small, Brent J et al. (2016) Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults. Int J Geriatr Psychiatry 31:502-9|
|Brown, Cassandra L; Robitaille, Annie; Zelinski, Elizabeth M et al. (2016) Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study. Psychol Aging 31:831-846|
|Thibeau, Sherilyn; McFall, G Peggy; Wiebe, Sandra A et al. (2016) Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study. Neuropsychology 30:6-17|
|McFall, G Peggy; Sapkota, Shraddha; McDermott, Kirstie L et al. (2016) Risk-reducing Apolipoprotein E and Clusterin genotypes protect against the consequences of poor vascular health on executive function performance and change in nondemented older adults. Neurobiol Aging 42:91-100|
|Caplan, Jeremy B; Bottomley, Monica; Kang, Pardeep et al. (2015) Distinguishing rhythmic from non-rhythmic brain activity during rest in healthy neurocognitive aging. Neuroimage 112:341-52|
|Martin, Sophie; Mazzocco, ClÃ©mence; Maury, Pascale et al. (2015) Compensating for memory losses throughout aging: validation and normalization of the memory compensation questionnaire (MCQ) for non-clinical French populations. Arch Gerontol Geriatr 60:28-38|
|Anstey, Kaarin J; Eramudugolla, Ranmalee; Hosking, Diane E et al. (2015) Bridging the Translation Gap: From Dementia Risk Assessment to Advice on Risk Reduction. J Prev Alzheimers Dis 2:189-198|
|McFall, G Peggy; Wiebe, Sandra A; Vergote, David et al. (2015) Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults. Alzheimers Dement (Amst) 1:395-402|
|McFall, G Peggy; Wiebe, Sandra A; Vergote, David et al. (2015) ApoE and pulse pressure interactively influence level and change in the aging of episodic memory: Protective effects among Îµ2 carriers. Neuropsychology 29:388-401|
|Sapkota, Shraddha; Vergote, David; Westaway, David et al. (2015) Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E. Neurobiol Aging 36:249-56|
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