Occupationally-related low back injury and the resulting disability represent national health and economic problems of crisis proportions. For instance, medical costs associated with low back disorders are estimated to exceed 50 billion dollars annually. In attempts to protect workers from back injury during manual materials handling, significant progress has been made in the development of engineering models witch predict the muscular and spinal forces associated with specific lifting task. Unfortunately, relatively little is known regarding how these spinal forces are, in turn, linked to injury. This is the gap the research is intended to fill. Current injury tolerance criteria are based, in part on in vitro human cadaveric testing which describes the compressive strength of lumbar vertebral bodies. However, it is apparent that repeated spinal stress can lead to disc degeneration, and increased risk of injury, through more subtle, biologic pathways. With cadaveric testing, the body's normal process of degeneration due to cumulative loading and repair are missed. To clarify these factors, animal models can provide an important adjunct to cadaveric testing. However, no animal data currently exists which links the biological and biomechanical response of the disc to various static and dynamic loading regimens. Therefore, we have developed a mouse tail model in which controlled compressive stress can be applied to the intervertebral disc, and the biologic and biomechanical consequences monitored. Using this animal model preliminary studies demonstrate that disc degeneration is proportional to the magnitude, frequency, and duration of spinal loading. The goal of this proposal is to use these preliminary results and collect biological and biomechanical data from animals subjected to various spinal loading regimens in vivo. These data will be used to develop and validate a mathematical model that quantifies the degenerative response of the disc to various durations of dynamic compressive loading. Final results will be in the form that is appropriate for future combination with existing biomechanical lifting models, which together, can be used to refine occupational lifting limits.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR046173-04
Application #
6375230
Study Section
Safety and Occupational Health Study Section (SOH)
Program Officer
Panagis, James S
Project Start
1998-09-30
Project End
2003-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
4
Fiscal Year
2001
Total Cost
$197,340
Indirect Cost
Name
University of California San Francisco
Department
Orthopedics
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Cheng, Kevin K; Berven, Sigurd H; Hu, Serena S et al. (2014) Intervertebral discs from spinal nondeformity and deformity patients have different mechanical and matrix properties. Spine J 14:522-30
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Rannou, Francois; Lee, Tzong-Shyuan; Zhou, Rui-Hai et al. (2004) Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am J Pathol 164:915-24
Walsh, Andrew J L; Lotz, Jeffrey C (2004) Biological response of the intervertebral disc to dynamic loading. J Biomech 37:329-37
Hsieh, Adam H; Lotz, Jeffrey C (2003) Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs. Spine (Phila Pa 1976) 28:1781-8
Court, C; Colliou, O K; Chin, J R et al. (2001) The effect of static in vivo bending on the murine intervertebral disc. Spine J 1:239-45

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