The long-term goal of this project is to utilize newly available very high-speed optical coherence tomography (OCT) technology to guide surgical treatments of anterior eye diseases. Measuring aberrations in the optical surfaces of the cornea requires great precision. OCT is well known for its exquisite spatial resolution, but until recently it has not had sufficient speed to overcome the inherent biological motion of the eye and capture the shape of the cornea. The development of Fourier-domain (FD) OCT technology has made the requisite speed possible.
The specific aims are: (1) To develop a very high-speed anterior segment OCT instrument. An FD-OCT system capable of 26,000 axial scans/second and 5-5m resolution has been tested. Preliminary data show that it is able to map corneal thickness with a precision of 1-5m root-mean-square and measure corneal power with a precision of 0.2 diopters. Motion correction algorithms will be developed to further improve the precision. (2) To develop OCT-guided corneal laser surgery for the treatment of irregular and opacified corneas. Although wavefront sensing and Placido-ring topography have been used to guide laser corneal surgeries, they are often unable to make valid measurements of irregular corneas. Our preliminary results showed that OCT can reliably make measurements in these diseased corneas that are most in need of surgical remedy. Corneal thickness or topography maps obtained by the OCT system will be used to program the depth of femtosecond laser corneal dissection and excimer laser ablation. OCT-guided femtosecond laser lamellar keratoplasty and excimer laser phototherapeutic keratectomy (PTK) will be tested in rabbit studies. Patients with corneal scar, ectasia, dystrophy, or irregular astigmatism following corneal surgery will be scanned, and laser surgery will be simulated by computer to evaluate the visual outcome. The simulation will take into account measurement variability, laser delivery error, healing effects, and visual optics. These tests will prepare for future human trials. (3) To develop an OCT-based intraocular lens (IOL) power formula. IOL power selection is difficult in patients who have had previous laser vision correction, often resulting in significant near- or far-sightedness after the cataract surgery. Laser ablation alters the natural relationship between the front and back corneal surfaces, causing error in conventional keratometry and IOL calculation. This increasingly common problem could be solved by measuring both anterior and posterior corneal powers with OCT. The OCT-based IOL formula will be tested in a clinical trial.
The aim of this project is to develop methods for imaging the cornea with a very high-speed and high-resolution optical coherence tomography (OCT) system that will precisely measure corneal thickness and shape and use this information to guide eye surgery. Patients with irregularly shaped or scarred corneas could have their vision restored by reshaping the corneas with a procedure that combines the precision of OCT and lasers instead of traditional corneal transplantation, which is associated with slow visual recovery and risks of transplant rejection. Cataract surgery in patients with previous laser vision correction often leads to significant near- or far-sightedness, a problem that could be resolved by using a more accurate intraocular lens power selection formula based on the measurement of corneal refractive power with OCT.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY018184-03
Application #
7777288
Study Section
Special Emphasis Panel (ZRG1-BDCN-F (12))
Program Officer
Wujek, Jerome R
Project Start
2008-03-01
Project End
2010-08-31
Budget Start
2010-03-01
Budget End
2010-08-31
Support Year
3
Fiscal Year
2010
Total Cost
$98,902
Indirect Cost
Name
University of Southern California
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Schallhorn, Julie M; Tang, Maolong; Li, Yan et al. (2017) Distinguishing between contact lens warpage and ectasia: Usefulness of optical coherence tomography epithelial thicknessĀ mapping. J Cataract Refract Surg 43:60-66
Wang, Li; Jiang, Lai; Hallahan, Katie et al. (2017) Evaluation of Femtosecond Laser Intrastromal Incision Location Using Optical Coherence Tomography. Ophthalmology 124:1120-1125
Skalet, Alison H; Li, Yan; Lu, Chen D et al. (2017) Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors. Ophthalmology 124:197-204
Li, Yan; Yokogawa, Hideaki; Tang, Maolong et al. (2017) Guiding flying-spot laser transepithelial phototherapeutic keratectomy with optical coherence tomography. J Cataract Refract Surg 43:525-536
Gao, Simon S; Jia, Yali; Zhang, Miao et al. (2016) Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci 57:OCT27-36
Ma, Jack X; Tang, Maolong; Wang, Li et al. (2016) Comparison of Newer IOL Power Calculation Methods for Eyes With Previous Radial Keratotomy. Invest Ophthalmol Vis Sci 57:OCT162-8
Li, Yan; Chamberlain, Winston; Tan, Ou et al. (2016) Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography. J Cataract Refract Surg 42:284-95
Tang, Maolong; Li, Yan; Chamberlain, Winston et al. (2016) Differentiating Keratoconus and Corneal Warpage by Analyzing Focal Change Patterns in Corneal Topography, Pachymetry, and Epithelial Thickness Maps. Invest Ophthalmol Vis Sci 57:OCT544-9
Su, Johnny P; Chandwani, Rahul; Gao, Simon S et al. (2016) Calibration of optical coherence tomography angiography with a microfluidic chip. J Biomed Opt 21:86015
Yokogawa, Hideaki; Tang, Maolong; Li, Yan et al. (2016) Deep Laser-Assisted Lamellar Anterior Keratoplasty With Microkeratome-Cut Grafts. Cornea 35:706-12

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