Abstract

The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter, cohort study in which a population-based sample of 6,500 Caucasian, Hispanic, African-American and Asian-American men and women aged 45-84 with subclinical cardiovascular disease are followed for 10 years to identify factors predictive of progression to overt cardiovascular disease. The MESA study is sponsored by NHLBI and is funded under contract. The MESA-EYE component (refraction and fundus photography) began in September 2002 at the second MESA visit.
The aims are to document the presence and severity of retinal microvascular changes (as read from digital retinal photos) indicative of macular degeneration and diabetic retinopathy and to describe their interrelationships with cross-sectional and longitudinal measures of macrovascular disease, including hypertension, diabetes, inflammation, endothelial dysfunction, and various markers of brain structure and function. The visual acuity/objective refraction component will allow us to estimate visual impairment by sex and ethnicity, determine the degree to which impairment could be reduced with better refractive correction, and to correlate visual impairment with fundus photography findings.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000403-01
Application #
6683971
Study Section
(EPIB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Liang, Dongchun; Zuo, Aijun; Shao, Hui et al. (2013) Retinoic acid inhibits CD25+ dendritic cell expansion and ?? T-cell activation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 54:3493-503
Yau, Joanne Wen Yee; Xie, Jing; Lamoureux, Ecosse et al. (2012) Retinal microvascular calibre and risk of incident diabetes: the multi-ethnic study of atherosclerosis. Diabetes Res Clin Pract 95:265-74
Greenstein, Max B; Myers, Chelsea E; Meuer, Stacy M et al. (2011) Prevalence and characteristics of choroidal nevi: the multi-ethnic study of atherosclerosis. Ophthalmology 118:2468-73
Kawasaki, Ryo; Cheung, Ning; Islam, F M Amirul et al. (2011) Is diabetic retinopathy related to subclinical cardiovascular disease? Ophthalmology 118:860-5
Yau, Joanne Wen Yee; Xie, Jing; Kawasaki, Ryo et al. (2011) Retinal arteriolar narrowing and subsequent development of CKD Stage 3: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 58:39-46
Ng, Ching Hui; Cheung, Ning; Wang, Jie Jin et al. (2011) Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population. Ophthalmology 118:694-9
Adar, Sara D; Klein, Ronald; Klein, Barbara E K et al. (2010) Air Pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based multi-ethnic study of atherosclerosis (MESA). PLoS Med 7:e1000372
Nguyen, Thanh T; Islam, F M Amirul; Farouque, H M Omar et al. (2010) Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke 41:1343-8
Jensen, Richard A; Shea, Steven; Ranjit, Nalini et al. (2010) Psychosocial risk factors and retinal microvascular signs: the multi-ethnic study of atherosclerosis. Am J Epidemiol 171:522-31
Kreis, Andreas J; Wong, Tien Yin; Islam, F M Amirul et al. (2009) Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA). Diab Vasc Dis Res 6:40-2

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