Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044617-07
Application #
2182621
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1990-07-01
Project End
1998-03-31
Budget Start
1996-08-01
Budget End
1998-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Daber, Robert; Sochor, Matthew A; Lewis, Mitchell (2011) Thermodynamic analysis of mutant lac repressors. J Mol Biol 409:76-87
Lewis, Mitchell (2011) A tale of two repressors. J Mol Biol 409:14-27
Milk, Leslie; Daber, Robert; Lewis, Mitchell (2010) Functional rules for lac repressor-operator associations and implications for protein-DNA interactions. Protein Sci 19:1162-72
Daber, Robert; Lewis, Mitchell (2009) A novel molecular switch. J Mol Biol 391:661-70
Hochschild, Ann; Lewis, Mitchell (2009) The bacteriophage lambda CI protein finds an asymmetric solution. Curr Opin Struct Biol 19:79-86
Daber, Robert; Lewis, Mitchell (2009) Towards evolving a better repressor. Protein Eng Des Sel 22:673-83
Daber, Robert; Sharp, Kim; Lewis, Mitchell (2009) One is not enough. J Mol Biol 392:1133-44
Daber, Robert; Stayrook, Steven; Rosenberg, Allison et al. (2007) Structural analysis of lac repressor bound to allosteric effectors. J Mol Biol 370:609-19
Lewis, M; Chang, G; Horton, N C et al. (1996) Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science 271:1247-54
Hoog, S S; Pawlowski, J E; Alzari, P M et al. (1994) Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily. Proc Natl Acad Sci U S A 91:2517-21

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