There is a need for better noninvasive imaging methods to detect and assess the nature of peripheral arterial disease for therapeutic planning and monitoring. With the emergence of angiogenetic agents and stem-cell transplantation as potentially new therapeutic options for patients with severe lower extremity ischemia, the importance of such noninvasive assessment methods is growing.
The aim of this research program is to develop and evaluate new magnetic resonance (MR) imaging methods aimed at enabling improved detection and characterization of patients with peripheral arterial disease. These new MR imaging tools include those to assess 1) lower extremity vessel anatomy, 2) global and regional perfusion, and 3) skin anatomy and physiology. The general hypothesis is that a new noninvasive and objective set of tools to characterize vascular anatomy, deep tissue and superficial skin perfusion, and skin morphology will provide a less morbid and more accurate predictor of therapy and outcome in patients with severe peripheral arterial disease. The research design will consist of technical studies leading to clinical studies evaluating the efficacy of these methods. The technical studies will be directed at developing and optimizing the various MR sequences and validating them under controlled situations. The clinical studies will be performed on patients with critical limb ischemia and skin pathology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL075803-04
Application #
7119217
Study Section
Special Emphasis Panel (ZHL1-CSR-I (S1))
Program Officer
Reid, Diane M
Project Start
2003-09-27
Project End
2008-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
4
Fiscal Year
2006
Total Cost
$503,902
Indirect Cost
Name
Stanford University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Kwon, Kie Tae; Kerr, Adam B; Wu, Holden H et al. (2015) Non-contrast-enhanced peripheral angiography using a sliding interleaved cylinder acquisition. Magn Reson Med 74:727-38
Ingle, R Reeve; Santos, Juan M; Overall, William R et al. (2015) Self-gated fat-suppressed cardiac cine MRI. Magn Reson Med 73:1764-74
Ingle, R Reeve; Wu, Holden H; Addy, Nii Okai et al. (2014) Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory. Magn Reson Med 72:347-61
Kwon, Kie Tae; Wu, Holden H; Shin, Taehoon et al. (2014) Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory. Magn Reson Med 71:1700-10
Björk, Marcus; Ingle, R Reeve; Gudmundson, Erik et al. (2014) Parameter estimation approach to banding artifact reduction in balanced steady-state free precession. Magn Reson Med 72:880-92
Dong, Hattie Z; Worters, Pauline W; Wu, Holden H et al. (2013) Noncontrast-enhanced renal angiography using multiple inversion recovery and alternating TR balanced steady-state free precession. Magn Reson Med 70:527-36
Shin, Taehoon; Worters, Pauline W; Hu, Bob S et al. (2013) Non-contrast-enhanced renal and abdominal MR angiography using velocity-selective inversion preparation. Magn Reson Med 69:1268-75
Shin, Taehoon; Hu, Bob S; Nishimura, Dwight G (2013) Off-resonance-robust velocity-selective magnetization preparation for non-contrast-enhanced peripheral MR angiography. Magn Reson Med 70:1229-40
Addy, Nii Okai; Wu, Holden H; Nishimura, Dwight G (2012) Simple method for MR gradient system characterization and k-space trajectory estimation. Magn Reson Med 68:120-9
Ingle, R Reeve; Cukur, Tolga; Nishimura, Dwight G (2012) The central signal singularity phenomenon in balanced SSFP and its application to positive-contrast imaging. Magn Reson Med 67:1673-83

Showing the most recent 10 out of 35 publications