Abstract

Peripheral arterial disease (PAD) is a major cause of disability in the United States. Despite the high prevalence of this disease, conventional evaluation of patients with this condition often lacks the sensitivity and specificity needed to make therapeutic decisions or to monitor potentially new treatment options such as stem-cell transplantation and angiogenic agents.
The aims of this project are to develop and evaluate new magnetic resonance imaging (MRI) methods for the improved assessment of peripheral arterial disease (PAD). The potential impact of this work is significant as it could lead to a new and improved noninvasive examination of this disease. This project will focus on the following areas: 1) three-dimensional (3D) blood- vessel imaging of the leg without the need for contrast agent injection, and 2) time-resolved 3D dynamic contrast-enhanced imaging of the lower leg for regional blood perfusion information. Substantial technical studies in these areas to develop and optimize the MRI methods will be followed by a pilot evaluative study on patients with PAD.

Public Health Relevance

There is a need for new and improved methods to assess peripheral arterial disease (PAD), a major source of disability in the United States. Magnetic resonance imaging (MRI) is a flexible and noninvasive modality that offers the potential to provide information to help diagnose and monitor patients with this disease. This research will develop, optimize, and evaluate new MRI methods designed for patients with PAD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL075803-06A1
Application #
7984076
Study Section
Clinical and Integrative Cardiovascular Sciences Study Section (CICS)
Program Officer
Reid, Diane M
Project Start
2003-09-27
Project End
2013-04-30
Budget Start
2010-08-01
Budget End
2011-04-30
Support Year
6
Fiscal Year
2010
Total Cost
$400,000
Indirect Cost

  Institution

Name
Stanford University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Kwon, Kie Tae; Kerr, Adam B; Wu, Holden H et al. (2015) Non-contrast-enhanced peripheral angiography using a sliding interleaved cylinder acquisition. Magn Reson Med 74:727-38
Ingle, R Reeve; Santos, Juan M; Overall, William R et al. (2015) Self-gated fat-suppressed cardiac cine MRI. Magn Reson Med 73:1764-74
Ingle, R Reeve; Wu, Holden H; Addy, Nii Okai et al. (2014) Nonrigid autofocus motion correction for coronary MR angiography with a 3D cones trajectory. Magn Reson Med 72:347-61
Kwon, Kie Tae; Wu, Holden H; Shin, Taehoon et al. (2014) Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory. Magn Reson Med 71:1700-10
Björk, Marcus; Ingle, R Reeve; Gudmundson, Erik et al. (2014) Parameter estimation approach to banding artifact reduction in balanced steady-state free precession. Magn Reson Med 72:880-92
Dong, Hattie Z; Worters, Pauline W; Wu, Holden H et al. (2013) Noncontrast-enhanced renal angiography using multiple inversion recovery and alternating TR balanced steady-state free precession. Magn Reson Med 70:527-36
Shin, Taehoon; Worters, Pauline W; Hu, Bob S et al. (2013) Non-contrast-enhanced renal and abdominal MR angiography using velocity-selective inversion preparation. Magn Reson Med 69:1268-75
Shin, Taehoon; Hu, Bob S; Nishimura, Dwight G (2013) Off-resonance-robust velocity-selective magnetization preparation for non-contrast-enhanced peripheral MR angiography. Magn Reson Med 70:1229-40
Addy, Nii Okai; Wu, Holden H; Nishimura, Dwight G (2012) Simple method for MR gradient system characterization and k-space trajectory estimation. Magn Reson Med 68:120-9
Ingle, R Reeve; Cukur, Tolga; Nishimura, Dwight G (2012) The central signal singularity phenomenon in balanced SSFP and its application to positive-contrast imaging. Magn Reson Med 67:1673-83

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