There is a need for better noninvasive imaging methods to detect and assess the nature of peripheral arterial disease for therapeutic planning and monitoring. With the emergence of angiogenetic agents and stem-cell transplantation as potentially new therapeutic options for patients with severe lower extremity ischemia, the importance of such noninvasive assessment methods is growing.
The aim of this research program is to develop and evaluate new magnetic resonance (MR) imaging methods aimed at enabling improved detection and characterization of patients with peripheral arterial disease. These new MR imaging tools include those to assess 1) lower extremity vessel anatomy, 2) global and regional perfusion, and 3) skin anatomy and physiology. The general hypothesis is that a new noninvasive and objective set of tools to characterize vascular anatomy, deep tissue and superficial skin perfusion, and skin morphology will provide a less morbid and more accurate predictor of therapy and outcome in patients with severe peripheral arterial disease. The research design will consist of technical studies leading to clinical studies evaluating the efficacy of these methods. The technical studies will be directed at developing and optimizing the various MR sequences and validating them under controlled situations. The clinical studies will be performed on patients with critical limb ischemia and skin pathology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL075803-02
Application #
6803969
Study Section
Special Emphasis Panel (ZHL1-CSR-I (S1))
Program Officer
Reid, Diane M
Project Start
2003-09-27
Project End
2008-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$479,464
Indirect Cost
Name
Stanford University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Ingle, R Reeve; Cukur, Tolga; Nishimura, Dwight G (2012) The central signal singularity phenomenon in balanced SSFP and its application to positive-contrast imaging. Magn Reson Med 67:1673-83

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