This project directly addresses the idea of etiological heterogeneity in ADHD in a prospective longitudinal design. Clarification of exophenotypic factor structure, in particular the role of sluggish cognitive tempo and of different assessment methods, is viewed as essential to provide an interpretive context for findings on mechanism heterogeneity.
The first aim therefore utilizes about 13,000 teacher ratings of symptoms of ADHD, oppositional/conduct, and sluggish tempo items to evaluate the fit of two, three, and four factor models of the domain.
The second aim i nstantiates a multi-level, multiple-pathway model in which the core constructs assessed are [a] regulatory control (related to the idea of cognitive control, executive function, and prefrontal neural systems) and [b] reactive response or approach (related to the idea of reward delay discounting and reinforcement learning). These constructs are assessed at three levels: cognitive task performance, physiological response, and child and parent trait ratings. Inclusion of multiple measures of both domains in the same study is among its chief innovations. Important moderating mechanisms will also be assessed, namely arousal/alertness and temporal information processing, and key family context variables are also assessed as moderators. 500 children will be recruited at age 7 years via a two stage population based sampling method in an effort to maximize the generalizability of the heterogeneity models that best fit these data. Analyses will evaluate which mechanism based measure best relates to different symptom domains and different ADHD subtypes.
The third aim more ambitiously attempts to break new ground in identifying ADHD subgroups validated by mechanism differences, using typological approaches to both the large teacher-rated sample and the 500 children with multiple measures of the core constructs. Three waves of data will be collected annually, and longitudinal analyses under each aim will evaluate types not only cross sectionally, but in terms of stability and change over time. It is hypothesized that when ADHD is accompanied by neurocognitive weakness it will have a more stable or deteriorating course. Results are aimed at making significant advances in empirical description of causal heterogeneity in ADHD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059105-09
Application #
7622098
Study Section
Special Emphasis Panel (ZRG1-BBBP-G (02))
Program Officer
Friedman-Hill, Stacia
Project Start
1999-09-20
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
9
Fiscal Year
2010
Total Cost
$657,335
Indirect Cost
Name
Oregon Health and Science University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Holton, Kathleen F; Nigg, Joel T (2016) The Association of Lifestyle Factors and ADHD in Children. J Atten Disord :
Stadler, Diane D; Musser, Erica D; Holton, Kathleen F et al. (2016) Recalled Initiation and Duration of Maternal Breastfeeding Among Children with and Without ADHD in a Well Characterized Case-Control Sample. J Abnorm Child Psychol 44:347-55
Martel, Michelle M; Levinson, Cheri A; Lee, Christine A et al. (2016) Impulsivity Symptoms as Core to the Developmental Externalizing Spectrum. J Abnorm Child Psychol :
Nigg, Joel T; Johnstone, Jeanette M; Musser, Erica D et al. (2016) Attention-deficit/hyperactivity disorder (ADHD) and being overweight/obesity: New data and meta-analysis. Clin Psychol Rev 43:67-79
Martel, Michelle M; Nigg, Joel T; Schimmack, Ulrich (2016) Psychometrically Informed Approach to Integration of Multiple Informant Ratings in Adult ADHD in a Community-Recruited Sample. Assessment :
Engelhardt, Paul E; Nigg, Joel T; Ferreira, Fernanda (2016) Executive function and intelligence in the resolution of temporary syntactic ambiguity: an individual differences investigation. Q J Exp Psychol (Hove) :1-19
Musser, Erica D; Karalunas, Sarah L; Dieckmann, Nathan et al. (2016) Attention-deficit/hyperactivity disorder developmental trajectories related to parental expressed emotion. J Abnorm Psychol 125:182-95
Ullsperger, Josie M; Nigg, Joel T; Nikolas, Molly A (2016) Does Child Temperament Play a Role in the Association Between Parenting Practices and Child Attention Deficit/Hyperactivity Disorder? J Abnorm Child Psychol 44:167-78
Ward, Anthony R; Alarcón, Gabriela; Nigg, Joel T et al. (2015) Erratum to: Variation in Parasympathetic Dysregulation Moderates Short-term Memory Problems in Childhood Attention-Deficit/Hyperactivity Disorder. J Abnorm Child Psychol 43:1585
Mitchell, Suzanne H; Wilson, Vanessa B; Karalunas, Sarah L (2015) Comparing hyperbolic, delay-amount sensitivity and present-bias models of delay discounting. Behav Processes 114:52-62

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