We propose """"""""An Integrated Pediatric Template of Brain Structure and Function"""""""" - a multivariate quantitative image assessment of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connectivity maturation. The parent project's over-arching aim is validate, construct and distribute a MRI-based statistical atlas (or template) that describes the developmental trajectory of blood flow patterns (or perfusion) in the """"""""normal"""""""" pediatric brain and its responses to working memory tasks. Here, we add depth to the imaging dataset collected from this large cohort through additional, state-of-the-art scanning. We also add rigor and breadth of appeal to the associated analysis by introducing cutting-edge computational neuroanatomy and multivariate statistical processing to tease out cross-modality interactions, network-node relationships and effects of these on cognitive processing. In particular, we achieve this through advanced diffusion tensor imaging, cutting-edge cortical thickness and analyses and multivariate sparse regression of the parameters, along with perfusion, and working memory performance.

Public Health Relevance

This proposal responds to public health needs through large-scale data collection that enables studies of cross-sectional sex differences in developmental trajectories and behavior. Secondly, the proposal supports longitudinal neuroimaging studies in mental disorders by performing a normative 4 time point multi-modality study of normal longitudinal development in 30 children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH080892-01A2S1
Application #
7815448
Study Section
Special Emphasis Panel (ZRG1-ETTN-B (95))
Program Officer
Cavelier, German
Project Start
2009-09-30
Project End
2010-05-04
Budget Start
2009-09-30
Budget End
2010-05-04
Support Year
1
Fiscal Year
2009
Total Cost
$21,498
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Jann, Kay; Hernandez, Leanna M; Beck-Pancer, Devora et al. (2015) Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder. Brain Behav 5:e00358

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