Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL020161-20
Application #
2215323
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Culbertson, A A; Keverline, K I; Klapper, D G et al. (1996) Investigation of the 35-62 conserved helix and disulfide loop of bovine prothrombin using an anti-peptide antibody. Int J Pept Protein Res 48:139-47
Deerfield 2nd, D W; Fox, D J; Head-Gordon, M et al. (1995) The first solvation shell of magnesium ion in a model protein environment with formate, water, and X-NH3, H2S, imidazole, formaldehyde, and chloride as ligands: an Ab initio study. Proteins 21:244-55
Cabaniss, S; Deerfield 2nd, D W; Monroe, D M et al. (1995) Is Ca(II) ion binding to prothrombin fragment 1 intrinsically cooperative, or is the cooperative binding accounted for by self-association? Blood Coagul Fibrinolysis 6:464-73
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Berkowitz, P; Huh, N W; Brostrom, K E et al. (1992) A metal ion-binding site in the kringle region of bovine prothrombin fragment 1. J Biol Chem 267:4570-6
Hamaguchi, N; Charifson, P; Darden, T et al. (1992) Molecular dynamics simulation of bovine prothrombin fragment 1 in the presence of calcium ions. Biochemistry 31:8840-8
Pearce, K H; Hiskey, R G; Thompson, N L (1992) Surface binding kinetics of prothrombin fragment 1 on planar membranes measured by total internal reflection fluorescence microscopy. Biochemistry 31:5983-95
Weber, D J; Berkowitz, P; Panek, M G et al. (1992) Modifications of bovine prothrombin fragment 1 in the presence and absence of Ca(II) ions. Loss of positive cooperativity in Ca(II) ion binding for the modified proteins. J Biol Chem 267:4564-9
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