PreDxion Bio, LLC is a precision medicine diagnostic company developing an assay platform (the MicroKine? assay cartridge and reader) that measures serum proteins in less than 30 minutes from a single drop of blood. This fast, actionable information allows for the first time individualized precision medicine aimed at reducing pediatric morbidity and mortality in pediatric sepsis, the number one killer of children worldwide. The goal of this STTR is to move the current research grade MicroKine? platform to a validated, scalable, commercial grade alpha platform (Phase I), then to a fully automated beta platform (Phase II), while demonstrating the feasibility of using the platform in the clinical workflow. Using serum sample from pediatric patients with sepsis PreDxion will validate the MicroKine? platform demonstrating the feasibility of rapid risk stratification and identification of therapeutic targets by addressing the following aims:
Specific Aim I) determine the feasibility of the alpha version of the MicroKine? assay to rapidly risk stratify pediatric patients with severe sepsis and Specific Aim II) demonstrate feasibility of rapidly determining the serum cytokines values in high-risk septic pediatric patients. Successful commercialization of the MicroKine? platform will provide the basis for expanding the current sepsis guidelines to individualized precision guidelines in high-risk individuals reducing the high rates of mortality in these individuals.

Public Health Relevance

PreDxion Bio is developing a rapid serum protein assay (MicroKine?) that will provide clinicians information to guide precise individual therapies to children at highest risk from dying from sepsis, the number one killer of children worldwide. The assay would change the current way children with sepsis are treated by providing serum inflammatory protein levels in less than 30 minutes allowing clinicians to act quickly. The MicroKine? assay provides this information from a drop of blood, a necessity when caring for children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
1R41HD090759-01
Application #
9253784
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Tamburro, Robert F
Project Start
2018-01-01
Project End
2018-06-30
Budget Start
2018-01-01
Budget End
2018-06-30
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Predxion Bio, Inc.
Department
Type
DUNS #
080356705
City
Dexter
State
MI
Country
United States
Zip Code
48130