The Department of Chemistry at Harvard University requests funds for the acquisition of two mass spectrometers. The first will be a high-performance, high-resolution mass spectrometer with electron impact (EI), chemical ionization, (CI) and fast atom bombardment (FAB) ionization capabilities; this instrument will be operated by trained operators. The second will be a general purpose instrument open to use by all qualified users. A core group of six faculty and their research teams will use these new instruments to characterize complex organic compounds. Research conducted by this group includes the synthesis of biologically active substances (such as prostaglandins, leukotrienes, thromboxanes, blood group substances, immunostimulators, antibiotics, antiviral agents, polypeptides, sugars, hormones and nucleic acids) and the determination of structures of natural products and synthetic intermediates.
| Abato, P; Conroy, J L; Seto, C T (1999) Combinatorial library of serine and cysteine protease inhibitors that interact with both the S and S' binding sites. J Med Chem 42:4001-9 |
| McGeoch, J E; Guidotti, G (1997) A 0.1-700 Hz current through a voltage-clamped pore: candidate protein for initiator of neural oscillations. Brain Res 766:188-94 |
| Erlanson, D A; Chytil, M; Verdine, G L (1996) The leucine zipper domain controls the orientation of AP-1 in the NFAT.AP-1.DNA complex. Chem Biol 3:981-91 |
| Choi, S K; Mammen, M; Whitesides, G M (1996) Monomeric inhibitors of influenza neuraminidase enhance the hemagglutination inhibition activities of polyacrylamides presenting multiple C-sialoside groups. Chem Biol 3:97-104 |
| Gao, J; Qiao, S; Whitesides, G M (1995) Increasing binding constants of ligands to carbonic anhydrase by using ""greasy tails"". J Med Chem 38:2292-301 |
