Continued support is requested fora training program in Viral Oncology at Duke University Medical Center. The program has been funded since 1975 and this is a request for renewal for the fifth term of the program. Funds are requested for the support of 5 predoctoral trainees and 2 postdoctoral trainees. The participating faculty consists of 16 members of the Duke University Medical Center, the majority of which have primary or secondary appointments in the Department of Molecular Genetics and Microbiology. The additional participating faculty have appointments in the Departments of Medicine, Pediatrics, Surgery, Biochemistry or Pharmacology and Cancer Biology. The research interests of the participating faculty range from basic molecular genetic studies of animal virus replication, to the use of DNA animal viruses as model systems for the study of gene regulation in eukaryotic cells, to the study of viral and cellular oncogene action, the immunology and molecular virology of the human immunodeficiency virus and the use of viruses in approaches to the treatment of human malignancies. The research program has proven to be an effective training basis for both predoctoral and postdoctoral trainees. The predoctoral program involves four semesters of academic work followed by a preliminary examination. Upon successful completion of these requirements, full time research occupies the remainder of the training program. The postdoctoral training program is focused on full time research in the participating laboratories. Both the predoctoral and the postdoctoral program are enhanced by departmental and program seminar series of various types as well as departmental retreats and an annual symposium on """"""""pathogenic human viruses."""""""" These activities also foster communication between members of the program to the ultimate benefit of trainees.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009111-35
Application #
8312346
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1980-07-01
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
35
Fiscal Year
2012
Total Cost
$316,972
Indirect Cost
$19,085
Name
Duke University
Department
Genetics
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Evans, M K; Sauer, S J; Nath, S et al. (2016) X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity. Cell Death Dis 7:e2073
Somarelli, J A; Schaeffer, D; Marengo, M S et al. (2016) Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. Oncogene 35:4302-11
Turpin, J; Ling, C; Crosby, E J et al. (2016) The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment. Oncogene 35:6053-6064
McFadden, Michael J; Gokhale, Nandan S; Horner, Stacy M (2016) Protect this house: cytosolic sensing of viruses. Curr Opin Virol 22:36-43
McFadden, Karyn; Hafez, Amy Y; Kishton, Rigel et al. (2016) Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. Proc Natl Acad Sci U S A 113:E782-90
Beachboard, Dia C; Horner, Stacy M (2016) Innate immune evasion strategies of DNA and RNA viruses. Curr Opin Microbiol 32:113-9
Suryadevara, Carter M; Riccione, Katherine A; Sampson, John H (2016) Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity. Clin Cancer Res 22:5164-5166
Kennedy, Edward M; Bogerd, Hal P; Kornepati, Anand V R et al. (2016) Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression. Cell Host Microbe 19:675-85
Desai, Rupen; Suryadevara, Carter M; Batich, Kristen A et al. (2016) Emerging immunotherapies for glioblastoma. Expert Opin Emerg Drugs 21:133-45
Gokhale, Nandan S; McIntyre, Alexa B R; McFadden, Michael J et al. (2016) N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe 20:654-665

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