This submission is for continuation of a graduate training program in investigative gastroenterology at Yale University. The program, which is in its 35th year, provides training in laboratory-based and patient-oriented research for: 1) physicians-scientists who have completed their clinical gastroenterology training (either in the Departments of Medicine or Pediatrics) to establish independent investigative careers in digestive tract research and 2) Ph.D. scientists who are seeking post-doctoral training in the biology of the digestive tract. Resources and mentors come from the Digestive Diseases Section, the Departments of Cell Biology, Cellular and Molecular Physiology, and Biology with the educational programs of the Yale Investigative Medicine Program (YIMP) and the Robert Wood Johnson Clinical Scholars Program. Preceptors have expertise in three primary areas: Intestinal epithelial biology and the microbiome, Cell biology, and Clinical/translational/genetic Sciences. Training opportunities in clinical and translational science have dramatically expanded over the most recent funded period, aided by recruitment of new preceptors and the development of new educational and degree programs. Training duration depends on the trainee background. Physician-trainees who have completed their clinical training will receive three years or more of research training;Ph.D.s with an interest in the digestive tract will receie two years of training. The trainees'curriculum includes didactic learning, research seminars, and journal clubs and their research will be presented locally and nationally. Formal application and interviews will be required to enter the program. Each trainee will have a progress committee comprised of their mentor, the Program Director (Fred Gorelick) or an Associate Director (Henry Binder or Judy Cho), a member of the Digestive Diseases faculty, and faculty from another section or department. Over the past 10 years, 27 trainees have entered the program and 21 will have completed their training by July 1, 2011. About 60% hold or have held full-time academic positions. The success of the Program with respect to Pediatric GI trainees has been particularly strong over the most recent funding period: all four have appointments as Assistant Professors and two are members of under- represented minorities. Renewal of the Clinical and Translational Science Award (CTSA) and establishment of a Yale Center for Scientific Teaching has substantially increased the resources and educational opportunities for our trainees.

Public Health Relevance

Diseases of the digestive tract have an enormous impact on our nation's health and healthcare costs. The goal of this proposal is to train MDs, MD,PhDs and PhDs for research careers studying intestinal and pancreatic disease with an ultimate goal of improving national health and reducing the cost of health care.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007017-38
Application #
8693616
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1977-01-01
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
38
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Sachar, Hamita; Pichetshote, Nipaporn; Nandigam, Kavitha et al. (2018) Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Gastrointest Endosc 87:1297-1303
Tang, Lieqi; Jiang, Lingli; McIntyre, Megan E et al. (2018) Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion. Sci Rep 8:7851
Manfredo Vieira, S; Hiltensperger, M; Kumar, V et al. (2018) Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 359:1156-1161
Parikh, Neil D; Viana, Artur V; Shah, Saloni et al. (2018) Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease. Scand J Gastroenterol 53:260-264
Nguyen-Dinh, Song-Huy; Do, Albert; Pham, Trang Ngoc Doan et al. (2018) High burden of hepatocellular carcinoma and viral hepatitis in Southern and Central Vietnam: Experience of a large tertiary referral center, 2010 to 2016. World J Hepatol 10:116-123
Njei, Basile; McCarty, Thomas R; Laine, Loren (2017) Early transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding. J Gastroenterol Hepatol 32:852-858
Clark, Brian T; Laine, Loren (2016) High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clin Gastroenterol Hepatol 14:1155-62
Clark, Brian T; Protiva, Petr; Nagar, Anil et al. (2016) Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 150:396-405; quiz e14-5
McCarty, Thomas R; Liu, Anne; Njei, Basile (2016) Splenic Injury and Hemoperitoneum as a Complication of Colonoscopy: A Case Report and Literature Review. Conn Med 80:217-21
Clark, Brian T; Parikh, Neil D; Laine, Loren (2016) Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointest Endosc 84:126-32

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