This submission is for continuation of a graduate training program in investigative gastroenterology at Yale University. The program, which is in its 35th year, provides training in laboratory-based and patient-oriented research for: 1) physicians-scientists who have completed their clinical gastroenterology training (either in the Departments of Medicine or Pediatrics) to establish independent investigative careers in digestive tract research and 2) Ph.D. scientists who are seeking post-doctoral training in the biology of the digestive tract. Resources and mentors come from the Digestive Diseases Section, the Departments of Cell Biology, Cellular and Molecular Physiology, and Biology with the educational programs of the Yale Investigative Medicine Program (YIMP) and the Robert Wood Johnson Clinical Scholars Program. Preceptors have expertise in three primary areas: Intestinal epithelial biology and the microbiome, Cell biology, and Clinical/translational/genetic Sciences. Training opportunities in clinical and translational science have dramatically expanded over the most recent funded period, aided by recruitment of new preceptors and the development of new educational and degree programs. Training duration depends on the trainee background. Physician-trainees who have completed their clinical training will receive three years or more of research training;Ph.D.s with an interest in the digestive tract will receie two years of training. The trainees'curriculum includes didactic learning, research seminars, and journal clubs and their research will be presented locally and nationally. Formal application and interviews will be required to enter the program. Each trainee will have a progress committee comprised of their mentor, the Program Director (Fred Gorelick) or an Associate Director (Henry Binder or Judy Cho), a member of the Digestive Diseases faculty, and faculty from another section or department. Over the past 10 years, 27 trainees have entered the program and 21 will have completed their training by July 1, 2011. About 60% hold or have held full-time academic positions. The success of the Program with respect to Pediatric GI trainees has been particularly strong over the most recent funding period: all four have appointments as Assistant Professors and two are members of under- represented minorities. Renewal of the Clinical and Translational Science Award (CTSA) and establishment of a Yale Center for Scientific Teaching has substantially increased the resources and educational opportunities for our trainees.

Public Health Relevance

Diseases of the digestive tract have an enormous impact on our nation's health and healthcare costs. The goal of this proposal is to train MDs, MD,PhDs and PhDs for research careers studying intestinal and pancreatic disease with an ultimate goal of improving national health and reducing the cost of health care.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007017-38
Application #
8693616
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
38
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Alper, Arik; Hardee, Steven; Rojas-Velasquez, Danilo et al. (2016) Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children. J Pediatr Gastroenterol Nutr 62:314-6
McCarty, Thomas R; Liu, Anne; Njei, Basile (2016) Splenic Injury and Hemoperitoneum as a Complication of Colonoscopy: A Case Report and Literature Review. Conn Med 80:217-21
Njei, Basile; McCarty, Thomas R; Laine, Loren (2016) Early TIPS in U.S. Patients Hospitalized with Acute Esophageal Variceal Bleeding. J Gastroenterol Hepatol :
Clark, Brian T; Parikh, Neil D; Laine, Loren (2016) Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointest Endosc 84:126-32
Clark, Brian T; Laine, Loren (2016) High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clin Gastroenterol Hepatol 14:1155-62
Clark, Brian T; Protiva, Petr; Nagar, Anil et al. (2016) Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 150:396-405; quiz e14-5
Hulur, Imge; Gamazon, Eric R; Skol, Andrew D et al. (2015) Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics 16:138
Zheng, Shasha; Hedl, Matija; Abraham, Clara (2015) TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages. J Immunol 194:1928-37
Zheng, Shasha; Hedl, Matija; Abraham, Clara (2015) Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators. J Immunol 195:217-26
Vilarinho, Sílvia; Taddei, Tamar H (2014) New frontier in liver cancer treatment: oncolytic viral therapy. Hepatology 59:343-6

Showing the most recent 10 out of 62 publications