The Cell, Molecular, and Genetics (CMG) Training Program at the University of California, San Diego is currently in its 25th year. This program is the foundation of the Ph.D. training effort in the biological sciences at UCSD, as it supports the very best graduate students from the Biology-Salk and Chemistry-Biochemistry Ph.D. programs. The mission of the CMG Training Program is to provide rigorous basic research training in cell biology, molecular biology, and genetics to outstanding young biomedical researchers in the earlier years of their doctoral studies. Specific emphasis is placed upon the creativity, quality, and impact of the research, the ethical conduct of research, the achievement of racial diversity among biomedical researchers, the ability of the trainees to communicate their results effectively, and the promotion of cooperation and collaboration among scientists. While the new director has already made an impressive impact and demonstrates significant potential for leading this program to a greater level of accomplishment, more time is needed to correct the weaknesses mentioned above. Thus, funding for three years at the current slot level is recommended to provide for a timelier reassessment of progress. The CMG Program Director is Dr. Jim Kadonaga. He has been a member of the Biology Department/Division at UCSD since 1988, and is currently Professor and Vice Chair of the Molecular Biology Section. Dr. Kadonaga works with an Advisory Committee for the CMG Training Program that consists of Drs. Lorraine Pillus, Steve Wasserman, Bart Sefton, Elizabeth Komives, and Bill McGinnis. There are currently 98 training faculty from the UCSD Division of Biology, Salk Institute, UCSD Department of Chemistry and Biochemistry, and Department of Cellular and Molecular Medicine at the UCSD Medical School. The CMG Training Program provides support for 45 outstanding Ph.D. students that are selected from a five-fold larger pool of eligible students (currently, 224 eligible students). The trainees fulfill the general requirements of their respective graduate programs and additionally participate in CMG-specific training activities, which include biannual CMG Training Program Symposia, annual One-on-One Conferences with the Program Director, and CMG Career Development Workshops. Over the past 10 years, 124 CMG trainees have successfully completed their Ph.D. thesis. Past and present CMG trainees have contributed an enormous wealth of fascinating and important knowledge to the biological sciences through a total of 411 publications (not including abstracts). With the projected growth of biology at UCSD, we envision the implementation of an even stronger CMG Training Program over the next five years.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007240-27
Application #
6603211
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
1975-07-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
27
Fiscal Year
2003
Total Cost
$1,155,821
Indirect Cost
Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Mulero, Maria Carmen; Shahabi, Shandy; Ko, Myung Soo et al. (2018) Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor ?B RelA Subunit. Biochemistry 57:2943-2957
Li, Wankun L; Chu, Monica W; Wu, An et al. (2018) Adult-born neurons facilitate olfactory bulb pattern separation during task engagement. Elife 7:
Loureiro, María Eugenia; Zorzetto-Fernandes, Andre Luiz; Radoshitzky, Sheli et al. (2018) DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog 14:e1007125
Piña, Francisco; Yagisawa, Fumi; Obara, Keisuke et al. (2018) Sphingolipids activate the endoplasmic reticulum stress surveillance pathway. J Cell Biol 217:495-505
E, Lezi; Zhou, Ting; Koh, Sehwon et al. (2018) An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. Neuron 97:125-138.e5
Lubin, Johnathan W; Tucey, Timothy M; Lundblad, Victoria (2018) Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo. Genetics 208:97-110
Morin, Manon; Pierce, Emily C; Dutton, Rachel J (2018) Changes in the genetic requirements for microbial interactions with increasing community complexity. Elife 7:
Rubin, Benjamin E; Huynh, TuAnh Ngoc; Welkie, David G et al. (2018) High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival. PLoS Genet 14:e1007301
Glustrom, Leslie W; Lyon, Kenneth R; Paschini, Margherita et al. (2018) Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function. Proc Natl Acad Sci U S A 115:10315-10320
Liu, Wanlu; Duttke, Sascha H; Hetzel, Jonathan et al. (2018) RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. Nat Plants 4:181-188

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