This application requests continued support for the doctoral training program in Dynamic Aspects of Chemical Biology in the Departments of Chemistry, Medicinal Chemistry, Molecular Biosciences, and Pharmaceutical Chemistry at the University of Kansas. This training program aims to educate doctoral graduates in the chemical sciences who will have a working level of biological information and skills, and doctoral graduates in the biological sciences who will have a command of chemical information and skills. The program at the University of Kansas takes advantage of a local tradition of over 50 years of close and effective collaboration among scientists at the interface of chemistry, biology, and the pharmaceutical sciences. Mentors will be drawn from the participating departments: 17 faculty from Chemistry, 12 from Molecular Biosciences, 8 from Medicinal Chemistry, and 6 from Pharmaceutical Chemistry. Support is requested for eight trainees, an increase of two from the previous submission. Trainees complete a program that features focused doctoral education and research in an area of established strength;a curriculum of courses that broadens the information and skills of trainees into areas beyond departmental boundaries;research rotations that giye trainees personal research experience in all areas of the program;and participation in both organization of and presentation at special seminars and an annual symposium. The doctoral research projects of trainees fall into a common theme of probing biological systems at the chemical level: (1) synthesis of biological probes;(2) delivery of probes across biological membranes;(3) structure and function of biological macromolecules;(4) detection and quantitation of probes in biological systems;and (5) functional genomics and bioinformatics. The training grant curriculum begins with core courses in bioinformatics and/or molecular modeling, principles of organic reactions and scientific integrity. Then each chemistry trainee is required to take a course in molecular biosciences and medicinal/pharmaceutical chemistry. A molecular biosciences student is required to take a course in chemistry and medicinal/pharmaceutical chemistry. Finally a student in medicinal/pharmaceutical chemistry student is required to take at least one elective course in molecular biosciences and chemistry. In addition, trainees meet all doctoral requirements of their home departments. Trainees manage and participate in the Annual Training Grant Symposium as well as in inviting speakers for a Chemical Biology seminar.

Public Health Relevance

At the heart of this proposal is the establishment of an integrated training program in the dynamic aspects of chemical biology. Integrated approaches that foster collaboration across scientific disciplines are paramount to gaining a broader understanding at the chemical biology interface with the ultimate goal of improving human health.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kansas Lawrence
Schools of Arts and Sciences
United States
Zip Code
Pickens, Chad J; Johnson, Stephanie N; Pressnall, Melissa M et al. (2018) Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide-Alkyne Cycloaddition. Bioconjug Chem 29:686-701
McFarlane, Jeffrey S; Davis, Cara L; Lamb, Audrey L (2018) Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase. J Biol Chem 293:8009-8019
Bart, Aaron G; Scott, Emily E (2018) Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands. J Biol Chem 293:19201-19210
Khandelwal, Anuj; Kent, Caitlin N; Balch, Maurie et al. (2018) Structure-guided design of an Hsp90? N-terminal isoform-selective inhibitor. Nat Commun 9:425
Mori-Quiroz, Luis M; Hedrick, Sidnee L; De Los Santos, Andrew R et al. (2018) A Unified Strategy for the Syntheses of the Isoquinolinium Alkaloids Berberine, Coptisine, and Jatrorrhizine. Org Lett 20:4281-4284
Ronnebaum, Trey A; Lamb, Audrey L (2018) Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study. Curr Opin Struct Biol 53:1-11
Sherwood, Alexander M; Williamson, Samuel E; Johnson, Stephanie N et al. (2018) Scalable Regioselective and Stereoselective Synthesis of Functionalized (E)-4-Iodobut-3-en-1-ols: Gram-Scale Total Synthesis of Fungal Decanolides and Derivatives. J Org Chem 83:980-992
Shin, Inchul; Ambler, Brett R; Wherritt, Daniel et al. (2018) Stepwise O-Atom Transfer in Heme-Based Tryptophan Dioxygenase: Role of Substrate Ammonium in Epoxide Ring Opening. J Am Chem Soc 140:4372-4379
Evans, Kara C; Benomar, Saida; Camuy-VĂ©lez, Lennel A et al. (2018) Quorum-sensing control of antibiotic resistance stabilizes cooperation in Chromobacterium violaceum. ISME J 12:1263-1272
Zhou, Yan; Crowley, Rachel; Prisinzano, Thomas et al. (2018) Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neurosci Lett 673:19-23

Showing the most recent 10 out of 120 publications