This exciting pre-doctoral training program at the Chemistry-Biology Interface involves 31 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). The mission of the CBITG at the University of Minnesota is to provide a diverse cadre of students with the skills necessary to cross traditional boundaries and understand and conduct scientific research at the interface of chemistry and biology. This mission will be accomplished by achieving the following objectives: (i) Provide students with an interdisciplinary training experience at the interface of chemistry and biology through a combination of coursework involving classes from at least two departments and by a cross-training experience involving a coadvisor and a research experience of three months in the coadvisor's laboratory. (ii) Expose students to cutting-edge science at the interface of chemistry and biology through seminars focused on this type of interfacial science (Chemical Biology Colloquium) and by allowing them to organize their own symposium focused on the chemical biology interface. (iii) Enhance the communication skills of trainees by providing them with multiple opportunities to present their research including a presentation at a national or international conference. (iv) Educate students about the range of career opportunities available for scientists with training in this area. (v) Stimulate interest in our training program through te use of interviews with trainees, trainers and prominent scientists working at the chemistry/biology interface. (vi) Increase the diversity of scientists carrying out research at the chemistry and biology interface in our program through a combination of different outreach activities. Trainees will be involved in research themes that include: Biocatalysis and Biomolecular Design (Distefano, Kazlauskas, Lipscomb, Ohlendorf, Schmidt-Dannert, Seelig Wackett, Wagner, Wilmot), Therapeutic Agents (Aldrich, Amin, Bernlohr, Distefano, Georg, Harki, Haskell-Luevano, Hoye, Mansky, Tretyakova, Wagner, Xing), Chemistry of Disease (Aldrich, Arriaga, Bernlohr, Distefano, Harki, Haskell-Luevano, Mansky, Murphy, Pomerantz, Tretyakova, Wagner, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Wackett, Wilmot), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Pomerantz, Tretyakova, Thomas, Veglia). The research groups of the training faculty are all well supported and well equipped. This highly successful training program has been ongoing for 14 years. In this period, support is requested for 8 trainees each year of the program, each to be supported for a two-year period.

Public Health Relevance

The trainers and their trainees collectively carry out research on fundamental questions related to current important problems in public health. These include understanding how cancers are initiated in the cell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs and probes for cancer, HIV and Alzheimer's disease, and understanding how chemicals are transformed and broken down in the environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008700-16
Application #
8667117
Study Section
(TWD)
Program Officer
Fabian, Miles
Project Start
1999-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Ming, Xun; Groehler 4th, Arnold; Michaelson-Richie, Erin D et al. (2017) Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells. Chem Res Toxicol 30:980-995
Jensen, Matthew R; Goblirsch, Brandon R; Christenson, James K et al. (2017) OleA Glu117 is key to condensation of two fatty-acyl coenzyme A substrates in long-chain olefin biosynthesis. Biochem J 474:3871-3886
Satori, Chad P; Ramezani, Marzieh; Koopmeiners, Joseph S et al. (2017) Checkpoints for Preliminary Identification of Small Molecules found Enriched in Autophagosomes and Activated Mast Cell Secretions Analyzed by Comparative UPLC/MSe. Anal Methods 9:46-54
Schaaf, Tory M; Peterson, Kurt C; Grant, Benjamin D et al. (2017) Spectral Unmixing Plate Reader: High-Throughput, High-Precision FRET Assays in Living Cells. SLAS Discov 22:250-261
Christenson, James K; Jensen, Matthew R; Goblirsch, Brandon R et al. (2017) Active Multienzyme Assemblies for Long-Chain Olefinic Hydrocarbon Biosynthesis. J Bacteriol 199:
Komor, Anna J; Rivard, Brent S; Fan, Ruixi et al. (2017) CmlI N-Oxygenase Catalyzes the Final Three Steps in Chloramphenicol Biosynthesis without Dissociation of Intermediates. Biochemistry 56:4940-4950
Schaaf, Tory M; Peterson, Kurt C; Grant, Benjamin D et al. (2017) High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA. SLAS Discov 22:262-273
Christenson, James K; Richman, Jack E; Jensen, Matthew R et al. (2017) ?-Lactone Synthetase Found in the Olefin Biosynthesis Pathway. Biochemistry 56:348-351
Lee, Amani L; Gee, Clifford T; Weegman, Bradley P et al. (2017) Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles. ACS Nano 11:5623-5632
Jasniewski, Andrew J; Komor, Anna J; Lipscomb, John D et al. (2017) Unprecedented (?-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI. J Am Chem Soc 139:10472-10485

Showing the most recent 10 out of 112 publications