There is an existing need for talented veterinary scientists trained in basic and translational research who apply the principles of """"""""One Health"""""""" to discover the next generation of advances in medicine for the improvement of health in humans. This application for a new institutional T32 grant seeks funds to create an outstanding program for veterinarians to acquire the knowledge and skills in basic science, comparative medicine and translational research in order to develop and apply models of human disease for the purpose of improving human health. The specific goal of our Training Program is to nurture the development of DVM investigators in the broad field of biomedical research with the expectation that these individuals will go on to become independent investigators at academic institutions or industry. This will be achieved by pursing the following Specific Aims:
Aim 1) identify a diverse and well-qualified pool of applicants from across the country;
Aim 2) provide an inspiring didactic program that is tailored to each applicants learning agenda;
Aim 3) acquaint trainees with the ongoing approaches for basic and translational research related to human disease;
Aim 4) mentor the trainees in the design, execution, evaluation and presentation of experiments leading to original research and giving the trainees the skills required for independent careers in academics. Through this program, trainees will gain knowledge and technical skills to fully understand and evaluate the pathogenesis of disease in humans as well as animal models of human disease through both didactic coursework and applied training in microbiology, immunology and comparative medicine. Trainees will be able to find mentorship from a successful group of scientists who are dedicated to research training. The mentors/thesis advisors are comprised mostly of experienced preceptors from basic and translational research programs in microbiology, immunology and comparative medicine that include a cadre of veterinarians with an established record in post- graduate training and mentorship of DVM graduates. Their research programs utilize collaborative and multi- disciplinary approaches employing state-of-the-art techniques in cell biology, microbiology, molecular biology and comparative pathology. By observing strong, interactive programs in multiple departments at UCSD and throughout the research community in San Diego, the trainees will have an outstanding opportunity to pursue an agenda for successful professional development. This training program will be administered by faculty associated with the UCSD Center for Veterinary Sciences and Comparative Medicine. As a result of this training program, trainees will gain a comprehensive understanding of hypothesis-based research and gain knowledge and skills required for productive careers in academics that will address the national needs for the development of skilled scientists in mouse pathobiology and comparative medicine relevant to human health.

Public Health Relevance

There is an existing need for skilled scientists trained in basic and translational research to lead the next generation of advances in medicine that will improve human health. This application for an institutional T32 grant seeks funds to create an outstanding program for veterinarians to acquire the knowledge and skills in basic science and comparative medicine in order to develop and apply models of human disease for the purpose of improving human health.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZOD1-CM-6 (02))
Program Officer
Moro, Manuel H
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Gaffney, P M; Witte, C; Clifford, D L et al. (2016) Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors. Vet Pathol 53:637-47
Annamalai, Karthikeyan; Gührs, Karl-Heinz; Koehler, Rolf et al. (2016) Polymorphism of Amyloid Fibrils In Vivo. Angew Chem Int Ed Engl 55:4822-5
Kurt, Timothy D; Sigurdson, Christina J (2016) Cross-species transmission of CWD prions. Prion 10:83-91
Das, Soumita; Sarkar, Arup; Choudhury, Sarmistha Sinha et al. (2015) ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol 1:311-324
Gaffney, Patricia M; Barr, Bradd; Rowe, Joan D et al. (2015) Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J 29:911-9
Vickers, T Winston; Clifford, Deana L; Garcelon, David K et al. (2015) Pathology and Epidemiology of Ceruminous Gland Tumors among Endangered Santa Catalina Island Foxes (Urocyon littoralis catalinae) in the Channel Islands, USA. PLoS One 10:e0143211
Kurt, Timothy D; Jiang, Lin; Fernández-Borges, Natalia et al. (2015) Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest 125:1485-96
Moriarty, Megan E; Vickers, T Winston; Clifford, Deana L et al. (2015) Ear Mite Removal in the Santa Catalina Island Fox (Urocyon littoralis catalinae): Controlling Risk Factors for Cancer Development. PLoS One 10:e0144271
Hiramatsu, Nobuhiko; Chiang, Wei-Chieh; Kurt, Timothy D et al. (2015) Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol 185:1800-8
Alam, M Samiul; Kuo, Jennifer L; Ernst, Peter B et al. (2014) Ecto-5'-nucleotidase (CD73) regulates host inflammatory responses and exacerbates murine salmonellosis. Sci Rep 4:4486