The Philippine Mollusk Symbiont ICBG (PMS ICBG) project links a biodiversity survey of marine mollusks in one of the world's hotspots of diversity, with drug discovery and enzyme bioprospecting aimed at bacterial symbionts of mollusks. Mollusks constitute the most diverse marine eukaryotic group, occupying virtually every possible ecological niche. The diversity of microbes associated with mollusks is equally vast. Within the mollusks, three particular groups exhibit what we believe to be the highest biotechnological and scientific potential: the bivalve family Teredinidae (genus Teredo) and the gastropod superfamilies Conoidea (genus Conus) and Muricoidea (genus Murex). The project directly addresses the goals of the ICBG program and will yield drug leads in central nervous system, cancer and antimicrobial areas, as well as strains and enzymes for cellulosic biofuels production. The project will characterize symbiotic diversity and pharmaceutical and biofuels potential of mollusk-associated bacteria in a comparative framework for the first time. The plan focuses on training, conservation, and the development of drug discovery and biofuels programs within the Philippines. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal and energy needs, consequent urgent conservation goals, and government and private sector commitment to education and technology to harness national human and natural resources for a sustainable future The project is led by Margo Haygood, marine microbiologist, Oregon Heath &Science University, in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Baldomero Olivera, biochemist, and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, evolutionary biologist, Academy of Natural Sciences, Philadelphia, and Daniel Distel, marine microbiologist, Ocean Genome Legacy.

National Institute of Health (NIH)
Fogarty International Center (FIC)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (52))
Program Officer
Katz, Flora N
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Engineering (All Types)
Schools of Medicine
United States
Zip Code
Lin, Zhenjian; Koch, Michael; Abdel Aziz, May Hamdy et al. (2014) Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus. Org Lett 16:4774-7
Lin, Zhenjian; Zachariah, Malcolm M; Marett, Lenny et al. (2014) Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis. J Nat Prod 77:1224-30
Puillandre, N; Bouchet, P; Duda Jr, T F et al. (2014) Molecular phylogeny and evolution of the cone snails (Gastropoda, Conoidea). Mol Phylogenet Evol 78:290-303
Lin, Zhenjian; Koch, Michael; Pond, Christopher D et al. (2014) Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp. J Antibiot (Tokyo) 67:121-6
Olivera, Baldomero M; Showers Corneli, Patrice; Watkins, Maren et al. (2014) Biodiversity of cone snails and other venomous marine gastropods: evolutionary success through neuropharmacology. Annu Rev Anim Biosci 2:487-513
Imperial, Julita S; Cabang, April B; Song, Jie et al. (2014) A family of excitatory peptide toxins from venomous crassispirine snails: using Constellation Pharmacology to assess bioactivity. Toxicon 89:45-54
Altamia, Marvin A; Wood, Nicole; Fung, Jennifer M et al. (2014) Genetic differentiation among isolates of Teredinibacter turnerae, a widely occurring intracellular endosymbiont of shipworms. Mol Ecol 23:1418-32
Lin, Zhenjian; Torres, Joshua P; Ammon, Mary Anne et al. (2013) A bacterial source for mollusk pyrone polyketides. Chem Biol 20:73-81
Lin, Zhenjian; Marett, Lenny; Hughen, Ronald W et al. (2013) Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorg Med Chem Lett 23:4867-9
Elshahawi, Sherif I; Trindade-Silva, Amaro E; Hanora, Amro et al. (2013) Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proc Natl Acad Sci U S A 110:E295-304

Showing the most recent 10 out of 15 publications