The intent of this application is to document the ability of the Johns Hopkins University to participate as an effective and productive clinical center in the proposed multicenter clinical trial, entitled """"""""Collaborative Initial Glaucoma Treatment Study"""""""" (CIGTS). This study's purpose is to evaluate whether initial treatment of open angle glaucoma is more effective by means of a stepped, medical regimen or by means of a surgical approach. The Johns Hopkins University's Clinical Center will participate in the CIGTS by identifying and recruiting eligible patients, administering the treatment regimen as assigned by the CIGTS's Coordinating Center and defined within the study's Manual of Operations, following and retaining study patients, recording and transferring study data to the Coordinating Center, and contributing to reports that will present the CIGTS results. This application describes the ability of the Johns Hopkins University Clinical Center to enroll approximately 29 patients per year, based upon pilot studies of patient eligibility conducted during a 3 month period. Details are provided of our plans to identify, recruit, follow, and retain these patients, our intent to obtain consistently high quality data on the visual outcomes of treatment, and the personnel and facilities available within our center to carry out the provisions of the CIGTS's Manual of Operations.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY009148-03
Application #
2162785
Study Section
Vision Research and Training Committee (VSN)
Project Start
1993-07-01
Project End
1998-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Musch, David C; Gillespie, Brenda W; Palmberg, Paul F et al. (2014) Visual field improvement in the collaborative initial glaucoma treatment study. Am J Ophthalmol 158:96-104.e2
Zahid, Sarwar; Musch, David C; Niziol, Leslie M et al. (2013) Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS). Am J Ophthalmol 155:674-680, 680.e1
Chen, Philip P; Musch, David C; Niziol, Leslie M (2011) The effect of early posttrabeculectomy intraocular pressure spike in the collaborative initial glaucoma treatment study. J Glaucoma 20:211-4
Radcliffe, Nathan M; Musch, David C; Niziol, Leslie M et al. (2010) The effect of trabeculectomy on intraocular pressure of the untreated fellow eye in the collaborative initial glaucoma treatment study. Ophthalmology 117:2055-60
Janz, Nancy K; Musch, David C; Gillespie, Brenda W et al. (2009) Evaluating clinical change and visual function concerns in drivers and nondrivers with glaucoma. Invest Ophthalmol Vis Sci 50:1718-25
Musch, David C; Gillespie, Brenda W; Lichter, Paul R et al. (2009) Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors. Ophthalmology 116:200-7
Musch, David C; Gillespie, Brenda W; Niziol, Leslie M et al. (2008) Factors associated with intraocular pressure before and during 9 years of treatment in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology 115:927-33
Janz, Nancy K; Wren, Patricia A; Guire, Kenneth E et al. (2007) Fear of blindness in the Collaborative Initial Glaucoma Treatment Study: patterns and correlates over time. Ophthalmology 114:2213-20
Jampel, Henry D; Frick, Kevin D; Janz, Nancy K et al. (2007) Depression and mood indicators in newly diagnosed glaucoma patients. Am J Ophthalmol 144:238-244
Musch, David C; Gillespie, Brenda W; Niziol, Leslie M et al. (2006) Cataract extraction in the collaborative initial glaucoma treatment study: incidence, risk factors, and the effect of cataract progression and extraction on clinical and quality-of-life outcomes. Arch Ophthalmol 124:1694-700

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