Core C, the Clinical/Statistical Core, supports the three research projects and the technology development project (TDP). The Core has three units: the Hope Clinic Unit at Emory University, Atlanta, GA;the Dengue Clinical Unit at Siriraj Hospital, Bangkok, Thailand;and the Statistical Unit at Emory University, Atlanta, GA. Projects 1-3 are focused on advancing our fundamental understanding of immune memory, innate immunity, and immunological senescence. The TDP will develop novel technology for single cell analysis of the transcriptional and epigenetic landscape of immune cells. This Core will provide Projects 1-3, and the TDP, with human clinical specimens and statistical support for studies of yellow fever virus (YFV) vaccine and dengue virus infection. The clinical core has four specific alms:
Aim 1) Provide expertise In conducting human research studies for successful completion of the CCHI scientific agenda. Core C activities Include: study design;clinical protocol and Informed consent document preparation and obtaining required regulatory approvals;recruitment of potential study participants;screening for eligibility, and enrollment;vaccinations; overall clinical study conduct according to Good Clinical Practice (GCP) standards;volunteer safety monitoring;clinical specimen collection, processing, and shipping;and preparation of progress reports, final reports, and publications.
Aim 2) Perform YFV vaccine clinical studies. The Hope Clinic Unit at Emory University will design and conduct clinical studies with YFV vaccine In adults. Clinical specimens from these studies will be analyzed to accomplish the scientific alms of Projects 1, 2, and 3, and the TDP.
Aim 3) Study immune responses in patients with dengue Infection. The Dengue Clinical Unit In Bangkok will design and conduct studies in hospitalized children and adults with dengue infection. Clinical specimens from this study will be analyzed to accomplish the scientific aims of Projects 1 and 2, and the TDP.
Aim 4) Provide statistical and data management expertise that ensures the success of the CCHI scientific agenda. The biostatistics unit will ensure adequate study design, assist with data storage and sharing, analyze data to Its maximum potential, and develop statistical methods for the data analysis as necessary.

Public Health Relevance

The work proposed is directly relevant to the health of the public. Vaccines have been our most effective weapons to battle Infectious diseases and protect public health. The work proposed will lead to better understanding of the immunological mechanisms that make a good vaccine successful (YFV) and will generate new knowledge of immunity to dengue infection, where new vaccines are critically needed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI057266-11
Application #
8724846
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2014-05-01
Project End
2019-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Type
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Fang, Fengqin; Yu, Mingcan; Cavanagh, Mary M et al. (2016) Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep 14:1218-31
Ravindran, Rajesh; Loebbermann, Jens; Nakaya, Helder I et al. (2016) The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 531:523-7
Chandele, Anmol; Sewatanon, Jaturong; Gunisetty, Sivaram et al. (2016) Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India. J Virol 90:11259-11278
Neu, Karlynn E; Henry Dunand, Carole J; Wilson, Patrick C (2016) Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease? Curr Opin Immunol 42:48-55
DiLillo, David J; Palese, Peter; Wilson, Patrick C et al. (2016) Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection. J Clin Invest 126:605-10
Henry Dunand, Carole J; Leon, Paul E; Huang, Min et al. (2016) Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell Host Microbe 19:800-13
Qi, Qian; Cavanagh, Mary M; Le Saux, Sabine et al. (2016) Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination. Sci Transl Med 8:332ra46
Ho, Irvin Y; Bunker, Jeffrey J; Erickson, Steven A et al. (2016) Refined protocol for generating monoclonal antibodies from single human and murine B cells. J Immunol Methods 438:67-70
Nakaya, Helder I; Clutterbuck, Elizabeth; Kazmin, Dmitri et al. (2016) Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. Proc Natl Acad Sci U S A 113:1853-8
Burke, Rachel M; Suchdev, Parminder S; Rebolledo, Paulina A et al. (2016) Predictors of Inflammation in a Cohort of Bolivian Infants and Toddlers. Am J Trop Med Hyg 95:954-963

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