The Statistical Core will provide the Center with highly qualified professionals witii skills in epidemiology, biostatistics, data management and computer technology. Under the leadership of Dr. Reed tiie statistical core will collaborate closely with each component of the Center in providing the resources for: efficient study design including appropriate sample size calculations and refinement of study procedures, database management, data analysis and reporting, manuscript and presentation development for study results, website development for efficient communication among projects, and training of project personnel in programming and website use as needed. The Core will be responsive and sensitive to the needs of the other components of the Center and that constitutes a truly collaborative team effort. The infrastructure for the Core already exists within the Biostatistics Research Group in tiie Division of Preventive and Behavioral Medicine which has provided design and analysis expertise, and data management resources to the Medical School for tiie past 10 years.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-MMT-M)
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University of Massachusetts Medical School Worcester
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Mavrogiorgos, Nikolaos; Mekasha, Samrawit; Yang, Yibin et al. (2014) Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response. Innate Immun 20:377-89
Del Tordello, Elena; Vacca, Irene; Ram, Sanjay et al. (2014) Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum. Proc Natl Acad Sci U S A 111:427-32
Agarwal, Sarika; Vasudhev, Shreekant; DeOliveira, Rosane B et al. (2014) Inhibition of the classical pathway of complement by meningococcal capsular polysaccharides. J Immunol 193:1855-63
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Lewis, Lisa A; Vu, David M; Granoff, Dan M et al. (2014) Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model. Infect Immun 82:2574-84
Rice, Peter A (2014) Editorial commentary: The shifting sands of gonococcal antimicrobial resistance. Clin Infect Dis 59:1092-4
Lewis, Lisa A; Vu, David M; Vasudhev, Shreekant et al. (2013) Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis. MBio 4:e00339-13
Daou, Nadine; Yu, Chunxiao; McClure, Ryan et al. (2013) Neisseria prophage repressor implicated in gonococcal pathogenesis. Infect Immun 81:3652-61
Granoff, Dan M; Ram, Sanjay; Beernink, Peter T (2013) Does binding of complement factor H to the meningococcal vaccine antigen, factor H binding protein, decrease protective serum antibody responses? Clin Vaccine Immunol 20:1099-107
Brookes, Charlotte; Kuisma, Eeva; Alexander, Frances et al. (2013) Development of a large scale human complement source for use in bacterial immunoassays. J Immunol Methods 391:39-49

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