The interface between the physical sciences and medicine is a new frontier for scientific exploration and, ultimately, for the creation of new and improved diagnostic and therapeutic tools to detect, treat, cure, and prevent human diseases. As an integral part of the Center for Cancer Physics, we propose to create a combined predoctoral and postdoctoral training program in physics of cancer that will be positioned at this interface and will establish a unique national resource with interdisciplinary and synergistic programs in fundamental research in cancer biology. This program will train predoctoral students and postdoctoral fellows across disciplines to lay foundations of cancer physics that will enable a new view of cancer cell function grounded in the physical sciences. The program will train a cadre of students and fellows for careers in research in academia by emphasizing eariy independence in research. Students and fellows will take advantage of research and clinical resources at the Johns Hopkins Hospital, including the NCI-designated Sidney Kimmel Comprehensive Cancer Center, the Ludwig Institute for Cancer Genetics and Therapeutics, the Sol Goldman Pancreatic Cancer Center, the In Vivo Cellular and Molecular Imaging Center, the unique educational resources and experimental facilities of the Johns Hopkins Institute for NanoBioTechnology (INBT website:, as well as the Washington University Medical School's NCI-designated Siteman Comprehensive Cancer Center, The Cancer Biology Program, the Siteman Center of Cancer Nanotechnology Excellence, and the Molecular Imaging Center, and at the University of North Carolina Medical School's NIH funded Curriculum in Bioinformatics and Computational Biology and NIH-funded Molecular and Cellular Biophysics Graduate Training Program.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-9)
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Johns Hopkins University
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Hielscher, Abigail; Gerecht, Sharon (2015) Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships. Free Radic Biol Med 79:281-91
Koride, Sarita; He, Li; Xiong, Li-Ping et al. (2014) Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber. Mol Biol Cell 25:3709-16
Aw Yong, Koh Meng; Zeng, Yu; Vindivich, Donald et al. (2014) Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis. J Cell Physiol 229:362-73
Capuano, Christopher M; Grzesik, Peter; Kreitler, Dale et al. (2014) A hydrophobic domain within the small capsid protein of Kaposi's sarcoma-associated herpesvirus is required for assembly. J Gen Virol 95:1755-69
Wang, Pu; Guan, Pei-Pei; Wang, Tao et al. (2014) Interleukin-1? and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism. Biochim Biophys Acta 1843:923-33
Stroka, Kimberly M; Konstantopoulos, Konstantinos (2014) Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration. Am J Physiol Cell Physiol 306:C98-C109
Li, Bo; Sun, Sean X (2014) Coherent motions in confluent cell monolayer sheets. Biophys J 107:1532-41
Stroka, Kimberly M; Jiang, Hongyuan; Chen, Shih-Hsun et al. (2014) Water permeation drives tumor cell migration in confined microenvironments. Cell 157:611-23
Wang, Ting; Gilkes, Daniele M; Takano, Naoharu et al. (2014) Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci U S A 111:E3234-42
Park, Kyung Min; Gerecht, Sharon (2014) Hypoxia-inducible hydrogels. Nat Commun 5:4075

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