Invasive cervical cancer (ICC) is a disease of disparities, with a higher risk among poor, rural, African American, Hispanic, and Native American women. ICC is preventable with adequate cytological screening, although there are several barriers to the access of screening and associated treatment for many high-risk women. The Behavioral Risk Factor Surveillance System (BRFSS) data show 13.3% of eligible women lacked screening for ICC in North Carolina within the last three years. We propose a pilot study to validate a mailed, at-home self-screening test for ICC. Among a sample of 200 women, we will explore psychological acceptance of the mailed self-administered screening test for ICC. Consenting rural women older than 30 years and lacking the proper screening schedule will recruited, asked to mail self-sampling kits, return mail cervico-vaginal specimens, and obtain HPV test results by telephone. HPV DNA positive, negative, and indetemriinate women will be referred to the North Carolina Breast and Cervical Cancer Control Program to conduct a second self-sampling at the clinic, a physician-collected sample for HPV and cytological screening, and, if indicated, follow-up treatment. Consultations with participants will be conducted to help identify barriers to self-screening and to follow-up screening and treatment in order to increase the effectiveness of this proposed outreach program. This pilot study will assess HPV detection rates for HPV self-test collected at home, and subsequent in-clinic self-collected and practitioner-collected samples. Genital specimens will be tested for high-risk types of human papillomavirus (HPV) infection with Quigen HC-ll assay. Standardized testing will optimize our efforts to evaluate the validity of this mailed self-sampling model. If successful, a mailed at-home self-screening test can immediately impact the delivery of preventive screening for many at-risk women. Pilot data would justify a scale-up to other high-risk regional and national areas, assuming the successful return of self-collected samples, sample quality is confirmed, and assurance of in-clinic screening and appropriate follow-up.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA156733-03
Application #
8379878
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$41,139
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Williams, Lindsay A; Olshan, Andrew F; Tse, Chui Kit et al. (2016) Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study. Cancer Causes Control 27:259-69
Chandar, Apoorva Krishna; Devanna, Swapna; Lu, Chang et al. (2015) Association of Serum Levels of Adipokines and Insulin With Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis. Clin Gastroenterol Hepatol 13:2241-55.e1-4; quiz e179
Linnan, Laura A; D'Angelo, Heather; Harrington, Cherise B (2014) A literature synthesis of health promotion research in salons and barbershops. Am J Prev Med 47:77-85
Bulsiewicz, W J; Dellon, E S; Rogers, A J et al. (2014) The impact of endoscopic ultrasound findings on clinical decision making in Barrett's esophagus with high-grade dysplasia or early esophageal adenocarcinoma. Dis Esophagus 27:409-17
Oh, Daniel S; Cheang, Maggie C U; Fan, Cheng et al. (2014) Radiation-induced gene signature predicts pathologic complete response to neoadjuvant chemotherapy in breast cancer patients. Radiat Res 181:193-207
Chen, Hao; Hu, Yuhui; Fang, Yu et al. (2014) Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut 63:711-9
Ren, Dongren; Zheng, Gaolin; Bream, Susan et al. (2014) Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus. Dig Dis Sci 59:57-63
Galbraith, Kayoll V; Gilkey, Melissa B; Smith, Jennifer S et al. (2014) Perceptions of mailed HPV self-testing among women at higher risk for cervical cancer. J Community Health 39:849-56
Fang, Yu; Chen, Hao; Hu, Yuhui et al. (2013) Gastroesophageal reflux activates the NF-κB pathway and impairs esophageal barrier function in mice. Am J Physiol Gastrointest Liver Physiol 305:G58-65
Orman, Eric S; Kim, Hannah P; Bulsiewicz, William J et al. (2013) Intestinal metaplasia recurs infrequently in patients successfully treated for Barrett's esophagus with radiofrequency ablation. Am J Gastroenterol 108:187-95; quiz 196

Showing the most recent 10 out of 17 publications