Career developmental program (CDP) is a particulariy important activity for translational research programs. By its very nature, translational research is multidisciplinary. Because ofthe depth of knowledge required of each individual discipline, our present edicational structure seldom allows trainees to function in a multidisciplinary environment. This Career Developmental Program is designed to provide the incentive and structure necessary to bring junior investigators into multidisciplinary translational research arena. A key to success of this endeavor is the availabililty and willingness of mentors throughout the SARC institutions to meet the challenges of translational research. This Program will be chaired by Dr. Richard Goriick, Director, Sarcoma Research Laboratory, Albert Einstein College of Medicine , Division Chief, Pediatric Hematology/Oncology, The Children's Hospital at Montefiore and Vice Chairman, Department of Pediatrics, The Children's Hospital at Montefiore and will be supported by the program Administrative Director, Denise Reinke, MS, NP, Chief Operating Officer of SARC. They are joined by a committee including leaders in the fields of medical oncology (Dr. Schuetze), pediatric oncology (Dr. Mackall), tumor biology (Dr. Lev), drug resistance (Dr. Hornicek), cancer genetics (Drs. Fletcher and van de Rijn), cancer statistics (Dr. Crowley), imaging biomarkers (Dr. Schwartz) and patient advocacy (Dr. Thorton). These outstanding senior mentors, representing Albert Einstein College of Medicine, Brigham and Women's Hospital, Cancer Research and Biostatistics (CRAB), Columbia University, Massachusetts General Hospital, MD Anderson, National Cancer Institute Intramural Program, Sarcoma Foundation Of America, Stanford University School ofMedicine, University of Michigan , have enthusiastically agreed to steward the SARC Sarcoma SPORE Career Developmental Program, with responsibility for selection and support of the SPORE career development awardees.
Providing research support and protected time for junior investigators is a general priority in translational cancer research, and particulariy so in sarcoma research, where the funding mechanisms are typically fewer than for other cancer disease types. SPORE support will improve the likelihood that each awardee will prceed to independent investigator status, and - in turn - these talented individuals will add dimension to the SARC Sarcoma SPORE.
|Choy, Edwin; Ballman, Karla; Chen, James et al. (2018) SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy. Sarcoma 2018:2068517|
|Yu, Peter Y; Lopez, Gonzalo; Braggio, Danielle et al. (2018) miR-133a function in the pathogenesis of dedifferentiated liposarcoma. Cancer Cell Int 18:89|
|Ignatius, Myron S; Hayes, Madeline N; Moore, Finola E et al. (2018) tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish. Elife 7:|
|Hawkins, Allegra G; Basrur, Venkatesha; da Veiga Leprevost, Felipe et al. (2018) The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling. Mol Cell Proteomics 17:901-912|
|Barrott, Jared J; Zhu, Ju-Fen; Smith-Fry, Kyllie et al. (2017) The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis. Mol Cancer Res 15:1733-1740|
|Ignatius, Myron S; Hayes, Madeline N; Lobbardi, Riadh et al. (2017) The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep 19:2304-2318|
|Kadoch, Cigall; Williams, Robert T; Calarco, Joseph P et al. (2017) Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. Nat Genet 49:213-222|
|Hayashi, Masanori; Baker, Alissa; Goldstein, Seth D et al. (2017) Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma. Oncotarget 8:78265-78276|
|Alomari, Ahmed K; Brown, Noah; Andea, Aleodor A et al. (2017) Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma. J Cutan Pathol 44:892-897|
|Svoboda, Laurie K; Bailey, Natashay; Van Noord, Raelene A et al. (2017) Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin. Oncotarget 8:458-471|
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