The CTSA funding to the Michigan Institute for Clinical and Health Research (MICHR) in 2007 marked the beginning of a transformation of clinical-translational research (CTR) at the University of Michigan (UM). This award, coupled with strong institutional support and growing faculty engagement, enabled UM to evolve from a predominantly basic science research institution to one with a comprehensive research portfolio. This has been achieved on the foundation of: integrated and innovative training and educational programs that have touched nearly 2,000 trainees, faculty and staff; centralization and optimization of previously fragmented research services to create innovative opportunities for users; $10.2M distributed for pilot studies to accelerate innovation; and researcher participation in new partnerships with our communities and across the CTSA National Consortium. In the renewal period, CTSA funding leveraged with robust institutional support will enable MICHR to pursue 5 Overarching Objectives: 1) Optimize training and mentoring to create the next generation of research teams and clinical and translational investigators; 2) Augment infrastructure and refine research services to reduce barriers and maximize research productivity across the entire translational research continuum; 3) Foster collaborations and leverage innovative approaches and technologies to catalyze discovery; 4) Enhance community- and practice-based partnerships to assure bi-directional learning, research, and implementation of findings to benefit health; 5) Actively lead and contribute to national CTSA Consortium activities and engage in cross-CTSA collaborations. These will be achieved by: expanding education into new areas to strengthen the pipeline of CTR investigators and deploying more flexible training tools; strengthening existing services and launching new ones to impact study start-up times and recruitment; employing major informatics investments to fully integrate the needs of CTR investigators into IT landscape; utilizing new practice-based research networks; expanding evaluation to efficiently assess and optimize our performance. MICHR will be the engine of improvement and innovation in the conduct of high-quality, high impact-clinical and translational research to advance the health of Michigan and the nation.
Translating scientific discoveries into real health gains is challenging. In recent decades this translation has been taking longer and costing more. The Michigan Institute for Clinical and Health Research provides infrastructure and services for researchers and increases access to research for the community. We help transform emerging knowledge into real changes in how we prevent and treat disease.
|Goldstein, Cathy A; Lanham, Michael S; Smith, Yolanda R et al. (2017) Sleep in women undergoing in vitro fertilization: a pilot study. Sleep Med 32:105-113|
|Pradarelli, Jason C; Scally, Christopher P; Nathan, Hari et al. (2017) Hospital Teaching Status and Medicare Expenditures for Complex Surgery. Ann Surg 265:502-513|
|Hardee, Jillian E; Cope, Lora M; Munier, Emily C et al. (2017) Sex differences in the development of emotion circuitry in adolescents at risk for substance abuse: a longitudinal fMRI study. Soc Cogn Affect Neurosci 12:965-975|
|Soliman, Elsayed Z; Ambrosius, Walter T; Cushman, William C et al. (2017) Effect of Intensive Blood Pressure Lowering on Left Ventricular Hypertrophy in Patients With Hypertension: SPRINT (Systolic Blood Pressure Intervention Trial). Circulation 136:440-450|
|Lee, Yvonne C; Bingham 3rd, Clifton O; Edwards, Robert R et al. (2017) Pain Sensitization is Associated with Disease Activity in Rheumatoid Arthritis Patients: A Cross-Sectional Study. Arthritis Care Res (Hoboken) :|
|Calinescu, Anda-Alexandra; Yadav, Viveka Nand; Carballo, Erica et al. (2017) Survival and Proliferation of Neural Progenitor-Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism. Clin Cancer Res 23:1250-1262|
|Bassis, Christine M; Allsworth, Jenifer E; Wahl, Heather N et al. (2017) Effects of intrauterine contraception on the vaginal microbiota. Contraception 96:189-195|
|Dickson, Robert P; Erb-Downward, John R; Freeman, Christine M et al. (2017) Bacterial Topography of the Healthy Human Lower Respiratory Tract. MBio 8:|
|Mehdipanah, Roshanak; Schulz, Amy J; Israel, Barbara A et al. (2017) Neighborhood Context, Homeownership and Home Value: An Ecological Analysis of Implications for Health. Int J Environ Res Public Health 14:|
|Dickson, Robert P; Cox, Michael J (2017) Gut microbiota and protection from pneumococcal pneumonia. Gut 66:384|
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