Cell-cell signaling is a major strategy that vertebrate embryos employ to control their development. We are interested in the mechanistic understanding of a major signaling pathway mediated by Wnts in the control of vertebrate embryonic development, in particular, limb development and skeletal morphogeneis. Early in limb development, signaling molecules which include the Wnt family members determine where and when the late structures, i.e., skeletal elements will form. Skeletal morphogeneis in the limb occurs through endochondral bone formation in which chondrocytes (they form the cartilage) and osteoblasts (they secrete bone matrix) are differentiated from mesenchymal condensations. This is followed by sequential proliferation and maturation of both chondrocytes and osteoblasts, which are tightly regulated and coordinated to ensure proper morphogenesis of the skeletal system. In the past year, we have being working on three aspects of the project: (1) Wnt/beta-catenin signaling regulates mesenchymal progenitor cell differentiation;(2) Wnt signaling regulates liver stem cell self renewal and differentiation. (3) The Wnt/PCP pathway provides directional information in controlling embryonic morphogensis.

Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2012
Total Cost
$813,733
Indirect Cost
Name
National Human Genome Research Institute
Department
Type
DUNS #
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Andre, Philipp; Song, Hai; Kim, Wantae et al. (2015) Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development 142:1516-27
Zhao, Haixia; Zhou, Wenrong; Yao, Zhengju et al. (2015) Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol 398:242-54
Pryor, Sophie E; Massa, Valentina; Savery, Dawn et al. (2014) Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. Development 141:3153-8
Malhotra, Deepti; Yang, Yingzi (2014) Wnts' fashion statement: from body stature to dysplasia. Bonekey Rep 3:541
Greer, Yoshimi Endo; Westlake, Christopher J; Gao, Bo et al. (2014) Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis. Mol Biol Cell 25:1629-40
Boutin, Camille; Labedan, Paul; Dimidschstein, Jordane et al. (2014) A dual role for planar cell polarity genes in ciliated cells. Proc Natl Acad Sci U S A 111:E3129-38
Qu, Yibo; Huang, Yuhua; Feng, Jia et al. (2014) Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A 111:E2996-3004
Regard, Jean B; Malhotra, Deepti; Gvozdenovic-Jeremic, Jelena et al. (2013) Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19:1505-12
Andre, Philipp; Yang, Yingzi (2013) Reply to Mazzeu: Human mutations in RYK might cause Robinow syndrome. J Biol Chem 288:2906
Gao, Bo; Yang, Yingzi (2013) Planar cell polarity in vertebrate limb morphogenesis. Curr Opin Genet Dev 23:438-44

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