Abstract

Put Nanostructures to Work for Reading and Controlling Cell Behavior Younan Xia Department of Chemistry, University of Washington, Seattle, WA 98195 Abstract Nanostructures have received extensive attention for their promising applications in electronics, photonics, and information storage. I believe these minuscule structures also hold great potential for advancing biomedical research. In particular, I have always wanted to harness the power of nanostructures to radically change the way cell behavior is probed and regulated. Here I propose to develop the next generation of toolset for studying and manipulating cell activity by bringing together three classes of complementary nanostructures: gold nanocages capable of absorbing near infrared light and effectively converting it to heat; smart polymers capable of changing conformation in response to small variation in temperature; and enzymes. The stimuli-responsive polymer will be covalently attached to a specific position near the active

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s Pioneer Award (NDPA) (DP1)
Project #
5DP1OD000798-04
Application #
7487039
Study Section
Special Emphasis Panel (ZGM1-NDPA-G (P2))
Program Officer
Jones, Warren
Project Start
2006-09-28
Project End
2011-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
4
Fiscal Year
2008
Total Cost
$760,000
Indirect Cost

  Institution

Name
Washington University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Zhu, Chunlei; Pongkitwitoon, Suphannee; Qiu, Jichuan et al. (2018) Design and Fabrication of a Hierarchically Structured Scaffold for Tendon-to-Bone Repair. Adv Mater 30:e1707306
Xue, Jiajia; Xie, Jingwei; Liu, Wenying et al. (2017) Electrospun Nanofibers: New Concepts, Materials, and Applications. Acc Chem Res 50:1976-1987
Zhang, Yu Shrike; Zhu, Chunlei; Xia, Younan (2017) Inverse Opal Scaffolds and Their Biomedical Applications. Adv Mater 29:
Zhang, Yu Shrike; Wang, Lihong V; Xia, Younan (2016) Seeing Through the Surface: Non-invasive Characterization of Biomaterial-Tissue Interactions Using Photoacoustic Microscopy. Ann Biomed Eng 44:649-66
Pang, Bo; Yang, Xuan; Xia, Younan (2016) Putting gold nanocages to work for optical imaging, controlled release and cancer theranostics. Nanomedicine (Lond) 11:1715-28
Lipner, Justin; Shen, Hua; Cavinatto, Leonardo et al. (2015) In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-to-Bone Repair. Tissue Eng Part A 21:2766-74
Zhang, Yu Shrike; Xia, Younan (2015) Multiple facets for extracellular matrix mimicking in regenerative medicine. Nanomedicine (Lond) 10:689-92
Yang, Xuan; Yang, Miaoxin; Pang, Bo et al. (2015) Gold Nanomaterials at Work in Biomedicine. Chem Rev 115:10410-88
Zhang, Yu Shrike; Yao, Junjie; Wang, Lihong V et al. (2014) Fabrication of Cell Patches Using Biodegradable Scaffolds with a Hexagonal Array of Interconnected Pores (SHAIPs). Polymer (Guildf) 55:445-452
Sun, Tianmeng; Wang, Yi; Wang, Yucai et al. (2014) Using SV119-gold nanocage conjugates to eradicate cancer stem cells through a combination of photothermal and chemo therapies. Adv Healthc Mater 3:1283-91

Showing the most recent 10 out of 112 publications