We have developed a new method to produce multivalent saccharide derivatives, which function as effective modulators of protein- carbohydrate interactions in cell-cell recognition. We propose to augment those studies by developing a synthesis of bivalent molecules bearing carbohydrate residues separated by specific distances. Our plan is to take advantage of the features of the ring opening metathesis polymerization to accomplish this goal. Oligomers generated by this method will then be used to explore the distance requirements for recognition by different cell surface receptors. These studies have implications for the modulation of protein-carbohydrate interactions in cell-cell recognition, inflammation, HTV infection, and other biological events.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM018750-03
Application #
2770840
Study Section
Special Emphasis Panel (ZRG2-PSF (04))
Project Start
1998-09-01
Project End
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715