This study of biomaterials research will address basic scientific problems with the potential for achieving significant advances in clinical orthopedic applications. This study is designed to synthesize a biomaterial which can be utilized in anterior cruciate ligament (ACL) repair. This investigation will use basic tissue engineering, mechanical testing and organic chemical principles to further understand artificial ligament repair. The proposed investigations to develop a scientific understanding of the relevant surface chemistry and mechanics at the ligament-ligament substitute and ligament substitute-bone interface. This investigation will attempt to synthesis a biocompatible ligament material using polymeric materials. When successful, the ligament substitute will open a major new direction for orthopedic clinical applications.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
3F31GM018905-03S1
Application #
6325007
Study Section
Special Emphasis Panel (ZRG2 (04))
Program Officer
Toliver, Adolphus
Project Start
1999-06-23
Project End
Budget Start
1999-06-23
Budget End
2001-06-22
Support Year
3
Fiscal Year
2000
Total Cost
$25,651
Indirect Cost
Name
Drexel University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Cooper Jr, James A; Sahota, Janmeet S; Gorum 2nd, W Jay et al. (2007) Biomimetic tissue-engineered anterior cruciate ligament replacement. Proc Natl Acad Sci U S A 104:3049-54
Cooper Jr, James A; Bailey, LeeAnn O; Carter, Janell N et al. (2006) Evaluation of the anterior cruciate ligament, medial collateral ligament, achilles tendon and patellar tendon as cell sources for tissue-engineered ligament. Biomaterials 27:2747-54
Lu, Helen H; Cooper Jr, James A; Manuel, Sharron et al. (2005) Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies. Biomaterials 26:4805-16
Cooper, James A; Lu, Helen H; Ko, Frank K et al. (2005) Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation. Biomaterials 26:1523-32
Laurencin, C T; Ambrosio, A M; Borden, M D et al. (1999) Tissue engineering: orthopedic applications. Annu Rev Biomed Eng 1:19-46