The proposal describes the continued development of allylsilane annulation chemistry in organic synthesis. The [3+2] annulation of allylsilanes is an effective route to the construction of five-member ring carbocycles, however, preparation of enantiomerically pure allylsilanes and participation of functionalized allylsilanes remain significant challenges. The proposal aim is to develop a new method for allylsilane synthesis that allows for facile structural manipulation and numerous enantiomerically pure allylsilanes, as well as, to expand the applications of this methodology by systematically introducing chemically diverse allylsilanes into annulation processes. Once achieved, allylsilane annulation chemistry exponentially increases in synthetic value and significantly raises the number of possible applications in target-driven syntheses.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31GM070401-02
Application #
6823199
Study Section
Special Emphasis Panel (ZRG1-F05 (29))
Program Officer
Toliver, Adolphus
Project Start
2004-01-01
Project End
2007-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
2
Fiscal Year
2005
Total Cost
$29,112
Indirect Cost
Name
University of California Irvine
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697