Stroke, or lack of blood flow to the brain, is a devastating disorder that affects 4.5 million people in the United States. Stroke survivors are often left with permanent neurologic deficits, including paralysis, blindness or sensory problems, which severely impact their quality of life. To date there is no effective treatment for stroke, or restoring lost neural tissue and proper brain circuitry. The purpose of the present study is to determine if adult human bone marrow stem cell therapy in rodent stroke lesions improves functional recovery and whether this recovery can be enhanced when combined with mAb IN-1 treatment.
Aims 1 and 2 will determine if stem cell therapy following stroke enhances sensorimotor function using a battery of behavioral tests and will assess new growth of neuronal pathways using the anterograde neuroanatomical tracer biotinylated dextran amine (BDA).
Aim 3 will determine if combination therapy of mAb IN-1 and stem cell treatment further enhances sensorimotor function and new growth of neuronal pathways. The results of these studies may lead to promising new approaches to help stroke survivors regain lost functions and significantly improve their quality of life.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS047012-02
Application #
6877070
Study Section
Special Emphasis Panel (ZRG1-F01 (20))
Program Officer
Owens, David F
Project Start
2004-04-01
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
2
Fiscal Year
2005
Total Cost
$27,182
Indirect Cost
Name
Loyola University Chicago
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153