This study will initiate the candidate's career goal of finding evidence to guide management of neuropsychiatric disturbances in dementia by allowing her training in PET imaging with a serotonin receptor-specific radioligand and statistical analysis. The synergistic expertise of the mentors and facilities available to her at the University of Toronto cannot be reproduced in the US for this study. HYPOTHESIS: Anxiety, obsessive-compulsive behaviors and dysphoria in frontotemporal lobar degeneration (FTLD) are associated with a diminution in 5HT1A receptor density in frontal and temporal cortex. PET imaging can demonstrate and quantify these differences.
SPECIFIC AIMS : 1) Quantify the difference in binding potential at 5HT1A receptors as derived from PET imaging with [11C]WAY-100635 in frontal and temporal cortical regions of interest between FTLD subjects and normal, age- and education-matched controls. 2) Compare the same PET findings between FTLD subjects with and without the mood symptoms. If changes in serotonergic function in frontal regions of interest correlate with the symptoms, this study will provide the basis for further investigations to identify serotonergic pharmacotherapy for such patients.
| Farb, Norman A S; Grady, Cheryl L; Strother, Stephen et al. (2013) Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation. Cortex 49:1856-73 |
| Chow, Tiffany W; Fam, David; Graff-Guerrero, Ariel et al. (2013) Fluorodeoxyglucose positron emission tomography in semantic dementia after 6ýýýmonths of memantine: an open-label pilot study. Int J Geriatr Psychiatry 28:319-25 |
| Links, Kira A; Black, Sandra E; Graff-Guerrero, Ariel et al. (2013) A case of apathy due to frontotemporal dementia responsive to memantine. Neurocase 19:256-61 |
| Chow, T W; Links, K A; Masterman, D L et al. (2012) A case of semantic variant primary progressive aphasia with severe insular atrophy. Neurocase 18:450-6 |
| Chow, Tiffany W; Graff-Guerrero, Ariel; Verhoeff, Nicolaas Plg et al. (2011) Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia. Neuropsychiatr Dis Treat 7:415-24 |
| Chow, T W; Gao, F; Links, K A et al. (2011) Visual rating versus volumetry to detect frontotemporal dementia. Dement Geriatr Cogn Disord 31:371-8 |
| Uchida, Hiroyuki; Chow, Tiffany W; Mamo, David C et al. (2011) Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections. Int J Geriatr Psychiatry 26:1300-8 |
| Links, K A; Merims, D; Binns, M A et al. (2010) Prevalence of primitive reflexes and Parkinsonian signs in dementia. Can J Neurol Sci 37:601-7 |
| Links, Kira A; Chow, Tiffany W; Binns, Malcolm et al. (2009) Apathy is not associated with basal ganglia atrophy in frontotemporal dementia. Am J Geriatr Psychiatry 17:819-21 |
| Chow, Tiffany W; Binns, Malcolm A; Cummings, Jeffrey L et al. (2009) Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type. Arch Neurol 66:888-93 |
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