This study will initiate the candidate's career goal of finding evidence to guide management of neuropsychiatric disturbances in dementia by allowing her training in PET imaging with a serotonin receptor-specific radioligand and statistical analysis. The synergistic expertise of the mentors and facilities available to her at the University of Toronto cannot be reproduced in the US for this study. HYPOTHESIS: Anxiety, obsessive-compulsive behaviors and dysphoria in frontotemporal lobar degeneration (FTLD) are associated with a diminution in 5HT1A receptor density in frontal and temporal cortex. PET imaging can demonstrate and quantify these differences.
SPECIFIC AIMS : 1) Quantify the difference in binding potential at 5HT1A receptors as derived from PET imaging with [11C]WAY-100635 in frontal and temporal cortical regions of interest between FTLD subjects and normal, age- and education-matched controls. 2) Compare the same PET findings between FTLD subjects with and without the mood symptoms. If changes in serotonergic function in frontal regions of interest correlate with the symptoms, this study will provide the basis for further investigations to identify serotonergic pharmacotherapy for such patients.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AG022802-03
Application #
6926183
Study Section
Special Emphasis Panel (ZRG1-F01 (20))
Program Officer
Molchan, Susan
Project Start
2003-09-01
Project End
2006-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
3
Fiscal Year
2005
Total Cost
$54,918
Indirect Cost
Name
Rotman Research Institute
Department
Type
DUNS #
City
Toronto
State
ON
Country
Canada
Zip Code
Farb, Norman A S; Grady, Cheryl L; Strother, Stephen et al. (2013) Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation. Cortex 49:1856-73
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Links, Kira A; Black, Sandra E; Graff-Guerrero, Ariel et al. (2013) A case of apathy due to frontotemporal dementia responsive to memantine. Neurocase 19:256-61
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Links, Kira A; Chow, Tiffany W; Binns, Malcolm et al. (2009) Apathy is not associated with basal ganglia atrophy in frontotemporal dementia. Am J Geriatr Psychiatry 17:819-21
Chow, Tiffany W; Binns, Malcolm A; Cummings, Jeffrey L et al. (2009) Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type. Arch Neurol 66:888-93

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