The objective of the proposed studies is to investigate the pattern of neural circuits linking orbitofrontal limbic and anterior temporal cortices. The significance of the proposed studies is based on the involvement of both areas in mnemonic, emotional, and high-order cognitive processes. Orbitofrontal limbic cortices and anterior temporal cortices are richly interconnected. This study will examine the patterns of connection of orbitofrontal areas and anterior temporal areas to identify common and unique circuits influencing the two distinct memory-related cortical areas. The pattern of origin and termination of interconnections between these areas will be examined with a goal to specify the strength of connections and their synaptic influence. Connections will be studied using retrograde and anterograde tracers to label neurons of origin and their termination. Understanding the bidirectional interaction of orbitofrontal limbic and anterior temporal areas may reveal characteristics that contribute to their common and unique roles in mnemonic, emotional, and cognitive processes, as well as their preferential susceptibility in neurologic disorders such as epilepsy, Alzheimer's disease, and schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH011151-02
Application #
2379153
Study Section
Cognitive Functional Neuroscience Review Committee (CFN)
Project Start
1997-07-23
Project End
Budget Start
1997-07-23
Budget End
1998-07-22
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Boston University
Department
Other Health Professions
Type
Schools of Allied Health Profes
DUNS #
042250712
City
Boston
State
MA
Country
United States
Zip Code
02215