Abstract

Excessive alcohol use (EAU) is becoming recognized as an emerging health-related problem especially among veterans returning from combats. There is a need for increased vigilance and action to identify and counsel these at-risk veterans. Unfortunately, we lack the reliable diagnostic tests to detect the dangerous levels of drinking. Such tests would be indispensable for screening and care for veterans with excessive alcohol use. We hypothesize that several novel serum and urine markers based on the effect of alcohol on immune cells can be used as the predictive biomarkers for EAU. To test this hypothesis, we plan to pursue the following specific aims.
SPECIFIC AIM # 1. To determine the effect of EAU on organ systems using system biology and by detecting, identifying, and comparing the relative quantity of these novel targets and evaluate these as potential biomarkers and SPECIFIC AIM # 2. To determine the predictive capacity of these biomarkers for alcohol-related health consequences. If successful, the results from this project will revolutionize the screening methods for veterans with excessive alcohol use.

Public Health Relevance

Excessive alcohol use (EAU) is becoming recognized as an emerging health-related problem especially among veterans returning from combats. Based on the results from our previous VA merit review funding, we found that several novel serum and urine markers based on the effect of alcohol on specific cell types can be used as the predictive biomarkers for EAU. We propose to systematically study these markers as the predictive of EAU and the quantity of recent alcohol consumption. Further, we will determine the predictive capacity of these markers for alcohol-related health consequences.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Non-HHS Research Projects (I01)
Project #
2I01CX000361-05A2
Application #
9351392
Study Section
Neurobiology A (NURA)
Project Start
2011-10-01
Project End
2021-09-30
Budget Start
2017-10-01
Budget End
2018-09-30
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Rlr VA Medical Center
Department
Type
DUNS #
608434697
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Hollister, Kristin; Kusumanchi, Praveen; Ross, Ruth Ann et al. (2018) Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis. Liver Res 2:52-59
Chang, Binxia; Hao, Shuli; Zhang, Longyu et al. (2018) Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease. Am J Med Sci 356:10-14
Jinjuvadia, Raxitkumar; Jinjuvadia, Chetna; Puangsricharoen, Pimpitcha et al. (2018) Concomitant Psychiatric and Nonalcohol-Related Substance Use Disorders Among Hospitalized Patients with Alcoholic Liver Disease in the United States. Alcohol Clin Exp Res 42:397-402
Walline, Crystal C; Blum, Janice S; Linton, Tobyn et al. (2018) Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study. J Investig Med 66:1-4
Li, Man; He, Yong; Zhou, Zhou et al. (2017) MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. Gut 66:705-715
Liangpunsakul, Suthat; Agarwal, Rajiv (2017) Altered circadian hemodynamic and renal function in cirrhosis. Nephrol Dial Transplant 32:333-342
Shen, Huafeng; Peng, Jennifer L; Tayarachakul, Sucharat et al. (2017) Association between serum cotinine level and prevalence of non-alcoholic fatty liver disease: a cross-sectional study from the Third National Health and Nutrition Examination Survey. J Investig Med 65:43-48
Jinjuvadia, Raxitkumar; Antaki, Fadi; Lohia, Prateek et al. (2017) The Association Between Nonalcoholic Fatty Liver Disease and Metabolic Abnormalities in The United States Population. J Clin Gastroenterol 51:160-166
Jinjuvadia, Raxitkumar; Salami, Augustine; Lenhart, Adrienne et al. (2017) Hepatocellular Carcinoma: A Decade of Hospitalizations and Financial Burden in the United States. Am J Med Sci 354:362-369
Zhao, Yulan; Wu, Jianguo; Liangpunsakul, Suthat et al. (2017) Long Non-coding RNA in Liver Metabolism and Disease: Current Status. Liver Res 1:163-167

Showing the most recent 10 out of 43 publications