The use of embryonic tissue for stem cell and genetic research raises numerous controversial ethical questions. However, little information exists about how decisions regarding such research specifically affect those women from whose gametes the embryos were created and their partners and families. This revised application for a Mentored Scientist Development Award in Research Ethics proposes a five-year course of study to investigate the impact of such new research methods on women. Dr. Lyerly completed a Greenwall Fellowship in Bioethics and Heath Policy at Johns Hopkins and Georgetown in 2001 and is now an Assistant Professor of Obstetrics and Gynecology at Duke University. Based on work she initiated at the National Bioethics Advisory Commission, Dr. Lyerly has begun collecting qualitative data through in-depth interviews on the attitudes of women who have undergone in vitro fertilization regarding potential research on their own cryopreserved embryos. Under the co-mentorship of nationally recognized leaders in research ethics, qualitative methods, and reproductive health, Drs. James Tulsky and Robert Cook-Deegan of Duke University and Dr. Ruth Faden of Johns Hopkins University, Dr. Lyerly proposes to use the observations of these qualitative data to formulate and validate a quantitative survey that will be distributed nationally and assess attitudes of individuals regarding their own cryopreserved embryos. The long-term goal of these studies will be to determine how genetic and stem cell research specifically impacts the women who serve as tissue donors. This is a group whose voice has not yet been introduced into this debate. Dr. Lyerly also proposes a rigorous course of study to further prepare her to be a leader as an empirical researcher in the ethics of reproductive healthcare. She will complete formal research methods training through the Master's program in clinical research at Duke. She will participate as a Faculty Associate at the Center for the Study of Medical Ethics and Humanities and continue work in the Center for Genome Ethics Law and Policy and the Center for Women's Studies. This proposal will support education, teaching and mentored research for the further development of a well-trained bioethicist focused on ethical issues regarding the impact of contemporary and future research on women.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01HL072437-03
Application #
7166094
Study Section
Special Emphasis Panel (ZRG1-HOP-E (50))
Program Officer
Werner, Ellen
Project Start
2004-12-17
Project End
2009-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
3
Fiscal Year
2007
Total Cost
$102,600
Indirect Cost
Name
Duke University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Harris, Lisa H; Cooper, Alexandra; Rasinski, Kenneth A et al. (2011) Obstetrician-gynecologists' objections to and willingness to help patients obtain an abortion. Obstet Gynecol 118:905-12
Lyerly, Anne Drapkin; Little, Margaret Olivia (2010) Toward an ethically responsible approach to vaginal birth after cesarean. Semin Perinatol 34:337-44
Lyerly, Anne Drapkin; Steinhauser, Karen; Voils, Corrine et al. (2010) Fertility patients' views about frozen embryo disposition: results of a multi-institutional U.S. survey. Fertil Steril 93:499-509
Namey, Emily E; Lyerly, Anne Drapkin (2010) The meaning of ""control"" for childbearing women in the US. Soc Sci Med 71:769-76
Lyerly, Anne Drapkin; Mitchell, Lisa M; Armstrong, Elizabeth Mitchell et al. (2009) Risk and the pregnant body. Hastings Cent Rep 39:34-42
Obstetrics and Gynecology Risk Research Group; Kukla, Rebecca; Kuppermann, Miriam et al. (2009) Finding autonomy in birth. Bioethics 23:1-8
Lyerly, Anne Drapkin; Little, Margaret Olivia; Faden, Ruth R (2009) The National Children's Study: a golden opportunity to advance the health of pregnant women. Am J Public Health 99:1742-5
Brown, Stephen D; Lyerly, Anne D; Little, Margaret O et al. (2008) Paediatrics-based fetal care: unanswered ethical questions. Acta Paediatr 97:1617-9
Little, Margaret Olivia; Lyerly, Anne Drapkin; Mitchell, Lisa M et al. (2008) Mode of delivery: toward responsible inclusion of patient preferences. Obstet Gynecol 112:913-8
Lyerly, Anne Drapkin; Little, Margaret Olivia; Faden, Ruth R (2008) A critique of the 'fetus as patient'. Am J Bioeth 8:42-4;discussion W4-6