The purpose of the proposed Mentored Scientist Career Development Award (K01) is to prepare the candidate with competencies to become an independent NIH-funded researcher. The candidate?s long-term goal is to develop expertise in HIV prevention research and in community-level HIV prevention design, implementation, and evaluation. The proposed research in the K01 period is to investigate the role of community-level mechanisms linking social capital to late HIV diagnosis in the United States (US). Late HIV diagnosis remains a persistent public health threat in the US; it is associated with poorer survival among HIV+ persons, and drives onward HIV transmission in the community. The association among social capital, mediating mechanisms and HIV diagnosis remains under-investigated in the US.
Aim 1 : To characterize the longitudinal relationship between social capital and late HIV diagnosis across race/ethnicity.
AIM 2 : To investigate mechanisms (HIV testing and HIV stigma) in relation to the association between social capital and late HIV diagnosis across race/ethnicity.
AIM 3 : To develop and pilot social capital indicators, tailored to HIV prevention. The candidate will develop additional training through didactic coursework in 1) advanced quantitative and qualitative research methods including spatial econometrics, ethnography, and community based participatory research; 2) epidemiologic/clinical study design, and 3) intervention development. The candidate will be mentored by a team of internationally renowned experts in HIV prevention research, social determinants of health, causal inference, and HIV surveillance systems. Mentor and advisory committee members are from Harvard University, City University of New York, Graduate School of Public Health and Health Policy, Emory University, and University of Pennsylvania. Institutional resources available to the candidate include Harvard Center for AIDS Research and The Fenway Institute. Findings from the proposed research will provide the competencies and preliminary data for the candidate to write an R01 or R34 proposal to develop, implement, and evaluate a community-level social capital-based HIV prevention intervention.

Public Health Relevance

/ Public Health Relevance Statement: The proposed research is to develop a deeper understanding on the role of social capital and late HIV diagnosis in the United States (US), and to better understand mechanisms that link the two. The project also aims to develop an indicator of social capital tailored to HIV prevention that is distinctly different from traditional indicators (e.g., social cohesion or collective efficacy). My research is significant because intervening at the stage of HIV diagnosis could have significant downstream impact on lowering community-level viral load suppression and reducing HIV incidence in key populations. Social capital is a modifiable determinant that can be generated and leveraged for community-level HIV prevention interventions in the US setting.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research & Training (K01)
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Special Emphasis Panel (ZRG1)
Program Officer
Greenwood, Gregory
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Yale University
Public Health & Prev Medicine
Schools of Medicine
New Haven
United States
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Dean, Lorraine T; Moss, Shadiya L; Ransome, Yusuf et al. (2018) ""It still affects our economic situation"": long-term economic burden of breast cancer and lymphedema. Support Care Cancer :
Ransome, Yusuf; Mayer, Kenneth H; Tsuyuki, Kiyomi et al. (2018) The Role of Religious Service Attendance, Psychosocial and Behavioral Determinants of Antiretroviral Therapy (ART) Adherence: Results from HPTN 063 Cohort Study. AIDS Behav :
Ransome, Yusuf; Thurber, Katherine A; Swen, Melody et al. (2018) Social capital and HIV/AIDS in the United States: Knowledge, gaps, and future directions. SSM Popul Health 5:73-85
Ransome, Yusuf; Dean, Lorraine T; Crawford, Natalie D et al. (2017) How Do Social Capital and HIV/AIDS Outcomes Geographically Cluster and Which Sociocontextual Mechanisms Predict Differences Across Clusters? J Acquir Immune Defic Syndr 76:13-22
Robinson, William T; Zarwell, Meagan; Gruber, DeAnn (2017) Preferences for Home-Based HIV Testing Among Heterosexuals at Increased Risk for HIV/AIDS: New Orleans, Louisiana, 2013. J Acquir Immune Defic Syndr 75 Suppl 3:S352-S356