Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01RR000104-02
Application #
2281136
Study Section
Special Emphasis Panel (CM)
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Krishnaswamy, S; Duan, S X; Von Moltke, L L et al. (2003) Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences. Xenobiotica 33:169-80
Krishnaswamy, Soundararajan; Duan, Su X; Von Moltke, Lisa L et al. (2003) Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6. Drug Metab Dispos 31:133-9
Court, Michael H; Freeman, Lisa M (2002) Identification and concentration of soy isoflavones in commercial cat foods. Am J Vet Res 63:181-5
Court, M H; Duan, S X; von Moltke, L L et al. (2001) Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 299:998-1006
Court, M H (2001) Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6. J Vet Pharmacol Ther 24:415-22
Court, M H; Duan, S X; Hesse, L M et al. (2001) Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology 94:110-9
Court, M H; Greenblatt, D J (2000) Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics 10:355-69
Ilkiw, J E (1999) Balanced anesthetic techniques in dogs and cats. Clin Tech Small Anim Pract 14:27-37
Court, M H; Hay-Kraus, B L; Hill, D W et al. (1999) Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences. Drug Metab Dispos 27:1293-9
Court, M H; Von Moltke, L L; Shader, R I et al. (1997) Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharm Drug Dispos 18:213-26

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