This application is for a competitive renewal of Dr. Elizabeth Stringer's International Research Scientist Development Award from the Fogarty International Center. Dr. Stringer requests an additional 2 years of support so that she can continue working toward her goal of becoming a competent and productive independent researcher in international women's health and clinical epidemiology. This goal will be pursued through the following activities: 1) completion of the MSc degree in epidemiology from the London School of Tropical Medicine and Hygiene; 2) completion of the long term follow-up portion of the randomized trial she successfully implemented during the initial portion of her Fogarty IRSDA; 3) conduct of three subanalyses from the randomized trial with assistance from her expert mentors; 4) conduct of a multi-site observational study of factors affecting women's utilization of services to prevent mother-to-child HIV transmission in Zambia. At the end of the 2-year grant period, the candidate will have substantial field experience in the design and conduct of both a randomized interventional trial and a large observational multi-site study and a qualification in epidemiology from a distinguished university. In addition, she will have had the opportunity, under the direction of her mentors, to merge the theoretical and the practical, and employ a variety of analytical techniques to the data she has gathered, including intent-to-treat proportional analysis and longitudinal/survival analysis in an interventional trial, techniques in repeated measures, and hierarchical mixed modeling. She will also have established two large epidemiological databases that will be available for analysis. At the end of her additional 2 years of support, Dr. Stringer will prepare and submit an R01 or other individual investigator application for independent funding. ? ? ?

National Institute of Health (NIH)
Fogarty International Center (FIC)
Research Scientist Development Award - Research & Training (K01)
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Special Emphasis Panel (ZRG1-ICP-3 (03))
Program Officer
Jessup, Christine
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University of Alabama Birmingham
Obstetrics & Gynecology
Schools of Medicine
United States
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Chi, Benjamin H; Mwango, Albert; Giganti, Mark et al. (2010) Early clinical and programmatic outcomes with tenofovir-based antiretroviral therapy in Zambia. J Acquir Immune Defic Syndr 54:63-70
Stringer, Elizabeth M; Levy, Jens; Sinkala, Moses et al. (2009) HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial. AIDS 23:1377-82
Chi, Benjamin H; Ellis, Giovanina M; Chintu, Namwinga et al. (2009) Intrapartum tenofovir and emtricitabine reduces low-concentration drug resistance selected by single-dose nevirapine for perinatal HIV prevention. AIDS Res Hum Retroviruses 25:1099-106
Cantrell, Ronald A; Sinkala, Moses; Megazinni, Karen et al. (2008) A pilot study of food supplementation to improve adherence to antiretroviral therapy among food-insecure adults in Lusaka, Zambia. J Acquir Immune Defic Syndr 49:190-5
Stringer, Elizabeth M; Chintu, Namwinga T; Levy, Jens W et al. (2008) Declining HIV prevalence among young pregnant women in Lusaka, Zambia. Bull World Health Organ 86:697-702
Chi, Benjamin H; Chintu, Namwinga; Cantrell, Ronald A et al. (2008) Addition of single-dose tenofovir and emtricitabine to intrapartum nevirapine to reduce perinatal HIV transmission. J Acquir Immune Defic Syndr 48:220-3
Mulenga, Lloyd B; Kruse, Gina; Lakhi, Shabir et al. (2008) Baseline renal insufficiency and risk of death among HIV-infected adults on antiretroviral therapy in Lusaka, Zambia. AIDS 22:1821-7
Chi, Benjamin H; Sinkala, Moses; Stringer, Elizabeth M et al. (2007) Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine. AIDS 21:957-64
Chi, Benjamin H; Sinkala, Moses; Mbewe, Felistas et al. (2007) Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial. Lancet 370:1698-705
Bolton-Moore, Carolyn; Mubiana-Mbewe, Mwangelwa; Cantrell, Ronald A et al. (2007) Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia. JAMA 298:1888-99

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