The University of California, San Diego (UCSD), Department of Psychiatry hereby applies on behalf of Tamara L. Wall for an Independent Scientist Award (KO2) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The overall aim of the proposed Research Career Award is to free the candidate from clinical and administrative duties so that she may devote nearly full-time to continue and develop further her research evaluating risk and protective factors for alcohol involvement within different ethnic groups. Asian Americans and Native American Indians vary greatly with respect to patterns, prevalences, and consequences of alcohol use. These differences are hypothesized to result from a combination of biological and psychosocial factors. This application has two overall goals: 1) to complete two projects currently funded by NIAAA focused on understanding the effects of genetic influences on response to alcohol in Asian Americans and Native American Indians; and 2) to expand upon these studies by evaluating the combined contributions of biological and psychosocial influences on alcohol drinking patterns and problems within these ethnic groups using cross-sectional, and eventually longitudinal, data. Results obtained from these studies will provide important information regarding the complex relationship between biological and environmental aspects of vulnerability to, and protection from, alcoholism. The candidate has made a strong commitment to alcohol-related research. Activities for her continued career development will include: 1) intensive new training with leading research scientists in the importance of psychosocial factors in developmental models of alcohol use and alcohol problems, statistical modeling techniques, and longitudinal research design; 2) coursework on advanced structural modeling and the responsible conduct of research; and 3) participation in department seminars and scientific meetings.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Scientist Development Award - Research (K02)
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Special Emphasis Panel (ZAA1-FF (01))
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University of California San Diego
Schools of Medicine
La Jolla
United States
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Luczak, Susan E; Liang, Tiebing; Wall, Tamara L (2017) Age of Drinking Initiation as a Risk Factor for Alcohol Use Disorder Symptoms is Moderated by ALDH2*2 and Ethnicity. Alcohol Clin Exp Res 41:1738-1744
Luczak, Susan E; Wall, Tamara L (2016) Gambling problems and comorbidity with alcohol use disorders in Chinese-, Korean-, and White-American college students. Am J Addict 25:195-202
Murray, Kate E; Klonoff, Elizabeth A; Garcini, Luz M et al. (2014) Assessing Acculturation Over Time: A Four-year Prospective Study of Asian American Young Adults. Asian Am J Psychol 5:252-261
Luczak, Susan E; Yarnell, Lisa M; Prescott, Carol A et al. (2014) Effects of ALDH2?2 on alcohol problem trajectories of Asian American college students. J Abnorm Psychol 123:130-40
Chartier, Karen G; Scott, Denise M; Wall, Tamara L et al. (2014) Framing ethnic variations in alcohol outcomes from biological pathways to neighborhood context. Alcohol Clin Exp Res 38:611-8
Otto, Jacqueline M; Hendershot, Christian S; Collins, Susan E et al. (2013) Association of the ALDH1A1*2 promoter polymorphism with alcohol phenotypes in young adults with or without ALDH2*2. Alcohol Clin Exp Res 37:164-9
Luczak, Susan E; Pandika, Danielle; Shea, Shoshana H et al. (2011) ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students. Alcohol Clin Exp Res 35:1238-45
Hendershot, Christian S; Witkiewitz, Katie; George, William H et al. (2011) Evaluating a cognitive model of ALDH2 and drinking behavior. Alcohol Clin Exp Res 35:91-8
McCarthy, Denis M; Pedersen, Sarah L; Lobos, Elizabeth A et al. (2010) ADH1B*3 and response to alcohol in African-Americans. Alcohol Clin Exp Res 34:1274-81
Hendershot, Christian S; Otto, Jacqueline M; Collins, Susan E et al. (2010) Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2. Ann Behav Med 40:77-88

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