? This career award will help the PI achieve the following career goals during the next five years by building on his strength in the statistical methodology, particularly the recursive partitioning based techniques, and on his experience of analyzing data related to substance use, and: ? ? (1) To further broaden his knowledge and enhance his understanding of human genetics, particularly related to genetic etiology of substance use disorders and interactions with environment. ? (2) To develop statistical methods that are of broad applications in analyzing biomedical data; to develop tree-based statistical methods and software for genetic analyses; to establish latent variable models and software for genetic analyses of ordinal traits; and to apply the new methods in on-going NIDA funded studies such as to better understand the genetic epidemiology of substance use disorders by considering an ordinal phenotypic definition that is a better reflection of how the substance use disorders were defined and recorded; and to identify candidate genes for tobacco use, and its comorbidity with alcohol use and psychiatric disorders including anxiety. ? (3) To establish and sustain a leadership role in statistical methodology and analysis for studying genetic epidemiology of substance use and related disorders by disseminating our methods and results through lectures, seminars, and conferences. ? (4) To strengthen his intellectual network inside and outside Yale particularly in studies of substance use. Understanding genetic epidemiology and environmental effects for complex diseases including substance use disorders remains a tremendous challenge. This award enables the PI to invest a major effort in a relatively long term to develop some of the critically needed, timely statistical methods and software, which help us advance our understanding of substance use disorders. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
1K02DA017713-01
Application #
6760684
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Weinberg, Naimah Z
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
1
Fiscal Year
2004
Total Cost
$151,508
Indirect Cost
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Chen, Xiang; Cho, Kelly; Singer, Burton H et al. (2011) The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. PLoS One 6:e16002
Lin, Haiqun; Williams, Kyle A; Katsovich, Liliya et al. (2010) Streptococcal upper respiratory tract infections and psychosocial stress predict future tic and obsessive-compulsive symptom severity in children and adolescents with Tourette syndrome and obsessive-compulsive disorder. Biol Psychiatry 67:684-91
Zhang, Heping; Liu, Ching-Ti; Wang, Xueqin (2010) An Association Test for Multiple Traits Based on the Generalized Kendall's Tau. J Am Stat Assoc 105:473-481
Ghebremichael, Musie; Paintsil, Elijah; Ickovics, Jeannette R et al. (2009) Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV. AIDS Care 21:834-41
Zhang, Heping; Wang, Minghui (2009) Search for the smallest random forest. Stat Interface 2:381
Zhang, Heping; Wang, Minghui; Chen, Xiang (2009) Willows: a memory efficient tree and forest construction package. BMC Bioinformatics 10:130
Chen, Xiang; Zhang, Heping (2009) The null distributions of test statistics in genomewide association studies. Stat Biosci 1:214-227
Feng, Rui; Zhou, Gongfu; Zhang, Meizhuo et al. (2009) Analysis of twin data using SAS. Biometrics 65:584-9
Merikangas, Kathleen R; Li, Julan Julia; Stipelman, Brooke et al. (2009) The familial aggregation of cannabis use disorders. Addiction 104:622-9
Levit, Orly; Jiang, Yuan; Bizzarro, Matthew J et al. (2009) The genetic susceptibility to respiratory distress syndrome. Pediatr Res 66:693-7

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