Applicant: I am an assistant professor in the Department of Physiology and Cell Biology at The Ohio State University. I currently have a teaching load equal to 30-35% effort, and a heavy service load; chair of graduate studies and 3 other dept. committees, recruitment member for our college-wide graduate program and secretary/treasurer of the Cardiovascular System Dynamics society. Upon award, my research time will more than double, and 90%+ off my total effort will be protected for research. Environment: The Ohio State University has provided me with adequate lab-space. I currently hold an AHA SDG, and a NHLBI RO1 to support my research. There is ample opportunity for scientific collaboration, and a wide array of core-facilities are at my disposal, including proteomics-, imaging-, and transgenic facilities. Research Plan: In plan to active participation in 2 weekly seminar series and 1 cardiovascular journal club, while official courses in responsible research practices will be taken. I will also be trained in small animal surgery, and do an internship in our departments' proteomics core facility. The research plan consists of three sections. In the first, I outline a summary of my currently funded RO1. As meanwhile we have made significant progress, in the second section I expanded that project with another aim: to elucidate the effects of myofilament responsiveness during various cardiac pathologies, using the methods and control data obtained with experiments covered in my RO1. In the third section, I proposed an additional line of research, that is related to the RO1 and its' expansion aims in methodological approaches, but has a distinct separate hypothesis. We postulate that heart rate variability (HRV; extensively and exclusively thought of as a marker for cardiac function), is actually a co-determinant of cardiac contractility. We have conducted preliminary experiments to show proof-of-principle of this novel concept, and will further investigate direct and indirect effects of HRV on cardiac function, including a possible novel therapeutic approach for cardiac failure.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02HL083957-02
Application #
7218693
Study Section
Special Emphasis Panel (ZHL1-CSR-O (F1))
Program Officer
Scott, Jane
Project Start
2006-04-06
Project End
2011-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
2
Fiscal Year
2007
Total Cost
$102,708
Indirect Cost
Name
Ohio State University
Department
Physiology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Beastrom, Nicholas; Lu, Haiyan; Macke, Allison et al. (2011) mdx(?cv) mice manifest more severe muscle dysfunction and diaphragm force deficits than do mdx Mice. Am J Pathol 179:2464-74
Haizlip, Kaylan M; Janssen, Paul M L (2011) In vitro studies of early cardiac remodeling: impact on contraction and calcium handling. Front Biosci (Schol Ed) 3:1047-57
Torres, Carlos A A; Janssen, Paul M L (2011) Contractile strength during variable heart duration is species and preload dependent. J Biomed Biotechnol 2011:294204
Chandrasekharan, Kumaran; Yoon, Jung Hae; Xu, Ying et al. (2010) A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Sci Transl Med 2:42ra54
Janssen, Paul M L (2010) Myocardial contraction-relaxation coupling. Am J Physiol Heart Circ Physiol 299:H1741-9
Janssen, Paul M L (2010) Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere. Am J Physiol Heart Circ Physiol 299:H1092-9
Bupha-Intr, Tepmanas; Haizlip, Kaylan M; Janssen, Paul M L (2009) Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro. Am J Physiol Heart Circ Physiol 296:H806-14
Varian, Kenneth D; Kijtawornrat, Anusak; Gupta, Subash C et al. (2009) Impairment of diastolic function by lack of frequency-dependent myofilament desensitization rabbit right ventricular hypertrophy. Circ Heart Fail 2:472-81
Gupta, Subash C; Varian, Kenneth D; Bal, Naresh C et al. (2009) Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits. Am J Physiol Heart Circ Physiol 296:H1933-9
Varian, Kenneth D; Xu, Ying; Torres, Carlos A A et al. (2009) A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium. Am J Physiol Heart Circ Physiol 297:H1940-8

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