Candidate: I am an assistant professor in the Department of Physiology and Cell Biology at the Ohio State University. My department equally values research, teaching, and service. Thus, I currently have a substantial teaching arid service load, which equates to ~60% of my effort. My short-term goals are to expand my research by learning new techniques and to gather new preliminary data to be used to apply for additional multi-year funding (R01, PPG). My long-term goals are to have at least two funded lines of research and to be a recognized leader in the field of nitric oxide signaling in cardiac hnyocytes. Environment: The College of Medicine at OSU greatly supports research. My department has provided me with adequate lab space. Currently, I am PI on a NHLBI R01 and a Co-l on another NHLBl R01. There are ample opportunities for collaboration and multiple core-facilities to which I have full access. Upon award, I will be removed from all service and some teaching commitments to double my research efforts. Research Plan: this plan consists of three sections, the first section is a summary of my R01. the second section is how I would like to expand this project. This (expansion consists of learning new techniques (small animal surgery

Public Health Relevance

Nitric oxide is an important regulator of heart function, the production of nitric oxide is altered in many cardiac diseases leading to dysfunction of the heart. The studies proposed here are relevant for public health by potentially improving the treatment of heart diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Scientist Development Award - Research (K02)
Project #
7K02HL094692-02
Application #
7754080
Study Section
Special Emphasis Panel (ZHL1-CSR-O (O1))
Program Officer
Carlson, Drew E
Project Start
2009-01-01
Project End
2013-12-31
Budget Start
2010-01-01
Budget End
2010-12-31
Support Year
2
Fiscal Year
2010
Total Cost
$104,166
Indirect Cost
Name
Ohio State University
Department
Physiology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Shettigar, Vikram; Zhang, Bo; Little, Sean C et al. (2016) Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease. Nat Commun 7:10794
Roof, Steve R; Ho, Hsiang-Ting; Little, Sean C et al. (2015) Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise. J Mol Cell Cardiol 81:54-61
Zhang, Bo; Davis, Jonathan P; Ziolo, Mark T (2015) Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect. J Vis Exp :e52618
Tang, Lifei; Wang, Honglan; Ziolo, Mark T (2014) Targeting NOS as a therapeutic approach for heart failure. Pharmacol Ther 142:306-15
Ziolo, Mark T; Houser, Steven R (2014) Abnormal Ca(2+) cycling in failing ventricular myocytes: role of NOS1-mediated nitroso-redox balance. Antioxid Redox Signal 21:2044-59
Biesiadecki, Brandon J; Davis, Jonathan P; Ziolo, Mark T et al. (2014) Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics. Biophys Rev 6:273-289
Curran, Jerry; Tang, Lifei; Roof, Steve R et al. (2014) Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. PLoS One 9:e87495
Sivakumaran, Vidhya; Stanley, Brian A; Tocchetti, Carlo G et al. (2013) HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxid Redox Signal 19:1185-97
Roof, Steve R; Tang, Lifei; Ostler, Joseph E et al. (2013) Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise. Basic Res Cardiol 108:332
Nixon, Benjamin R; Liu, Bin; Scellini, Beatrice et al. (2013) Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation. Arch Biochem Biophys 535:30-8

Showing the most recent 10 out of 19 publications