The candidate proposes new strategies to develop a research focused on improving treatment outcomes of geriatric mania and bipolar (BP) disorders. He and his colleagues will identify and test biologically meaningful predictors of response to mood stabilizer treatment. Findings are expected to improve the clinical management of geriatric mania, contribute to the understanding of treatment resistance, and open new avenues for innovative therapies for these highly disabling, yet understudied disorders. The candidate proposes to focus on the influence of neurocognitive impairments on treatment outcomes. He has obtained preliminary evidence that behavioral and neuroimaging indices of frontostriatal dysfunction are associated with poor outcomes in geriatric mania. He will use sophisticated assays of ventromedial-limbic as well as dorsolateral circuits to begin to define groups with differing functional and psychopathologic outcomes. The career enhancement plan will provide the candidate with additional background in cognitive neuroscience and in genetics that will be critical to conducting the multidisciplinary research program proposed. The training component is organized around two pilot studies and new collaborative relationships with experts in these areas. The award would also support extension of the candidate's leadership role in developing multicenter studies of geriatric mania and BP disorder; this development would enhance his own research and would provide a context for a broad range of investigation and training. The award will facilitate his contribution to new related initiatives in the Cornell IRC that pertain to this population. It will foster his mentoring of young investigators focusing on these patients. ? ?

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research (K02)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-CRB-B (03))
Program Officer
Evans, Jovier D
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Weill Medical College of Cornell University
Schools of Medicine
New York
United States
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Agarkar, Smita; Hurt, Stephen W; Young, Robert C (2018) Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder. Psychiatry Res 265:355-359
Mahgoub, Nahla; Young, Robert C (2017) Synthetic Cannabinoids Use in Elderly Patients. J Psychiatr Pract 23:230-232
Young, Robert C; Mulsant, Benoit H; Sajatovic, Martha et al. (2017) GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder. Am J Psychiatry 174:1086-1093
Sajatovic, Martha; Strejilevich, Sergio A; Gildengers, Ariel G et al. (2015) A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force. Bipolar Disord 17:689-704
Mahgoub, Nahla; Lerner, Michael; Kalayam, Balu et al. (2014) Symptoms and observations: differences in time course during electroconvulsive therapy in geriatric depressed patients. J ECT 30:e7-8
Beyer, John L; Greenberg, Rebecca L; Marino, Patricia et al. (2014) Social support in late life mania: GERI-BD. Int J Geriatr Psychiatry 29:1028-32
Sheeran, Thomas; Greenberg, Rebecca L; Davan, Laura A et al. (2012) A descriptive study of older bipolar disorder residents living in New York City's adult congregate facilities. Bipolar Disord 14:756-63
Harris, Yael T; Harris, Alexander Z; Deasis, Jose M et al. (2012) Cabergoline associated with first episode mania. Psychosomatics 53:595-600
Agarkar, Smita; Hurt, Stephen; Lisanby, Sarah et al. (2012) ECT use in unipolar and bipolar depression. J ECT 28:e39-40
Sajatovic, Martha; Gildengers, Ariel; Young, Robert C (2012) Late-life bipolar disorder: advances in treatment, conceptualization, and research methodology. J Geriatr Psychiatry Neurol 25:4-5

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