This 2nd revision of an application for a competing renewal of an Independent Scientist Award seeks funding to support development of the candidate's research on the treatment of late-life bipolar disorders and his mentorship of young investigators. This research program addresses the need for evidence that can help individualize the management of these underserved patients by examining proposed clinical and neurobiological predictors of inter-individual differences in benefit from first line pharmacotherapies. Having initiated the multi-center GERI-BD study of acute treatment of manic bipolar elders, and its Coordinating Center, the candidate aims to use this platform to explore the utility of selected measures of frontostriato-limbic impairment as predictors of resistance to anti-manic treatment. Three Pilot Studies will focus on affect-laden executive tasks, neuroimaging of white matter integrity, and neurotransmitter-related genetic variation. Conducting these Pilot Studies will enable the candidate to expand his knowledge base in cognitive and affective neuroscience, neuroimaging and pharmacogenetics, and related analytic issues, through interaction with expert advisor/collaborators. This career enhancement is intended to foster development of his research to address the needs of elderly patients who do poorly with optimal standard treatments, and to study the management of other phases of bipolar illness in late life. It is also intended to support continuation and expansion of his mentorship activity. As the population ages, greater numbers of elders present with bipolar disorder. They suffer from severe symptoms, disability, and high mortality. These studies can provide findings that use relatively non- invasive and cost effective methods, derived from neuroscience and neurobiology, to develop safe and effective treatment approaches.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research (K02)
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Application #
Study Section
Interventions Committee for Disorders Related to Schizophrenia, Late Life, or Personality (ITSP)
Program Officer
Evans, Jovier D
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Weill Medical College of Cornell University
Schools of Medicine
New York
United States
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Agarkar, Smita; Hurt, Stephen W; Young, Robert C (2018) Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder. Psychiatry Res 265:355-359
Mahgoub, Nahla; Young, Robert C (2017) Synthetic Cannabinoids Use in Elderly Patients. J Psychiatr Pract 23:230-232
Young, Robert C; Mulsant, Benoit H; Sajatovic, Martha et al. (2017) GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder. Am J Psychiatry 174:1086-1093
Sajatovic, Martha; Strejilevich, Sergio A; Gildengers, Ariel G et al. (2015) A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force. Bipolar Disord 17:689-704
Beyer, John L; Greenberg, Rebecca L; Marino, Patricia et al. (2014) Social support in late life mania: GERI-BD. Int J Geriatr Psychiatry 29:1028-32
Mahgoub, Nahla; Lerner, Michael; Kalayam, Balu et al. (2014) Symptoms and observations: differences in time course during electroconvulsive therapy in geriatric depressed patients. J ECT 30:e7-8
Sheeran, Thomas; Greenberg, Rebecca L; Davan, Laura A et al. (2012) A descriptive study of older bipolar disorder residents living in New York City's adult congregate facilities. Bipolar Disord 14:756-63
Harris, Yael T; Harris, Alexander Z; Deasis, Jose M et al. (2012) Cabergoline associated with first episode mania. Psychosomatics 53:595-600
Agarkar, Smita; Hurt, Stephen; Lisanby, Sarah et al. (2012) ECT use in unipolar and bipolar depression. J ECT 28:e39-40
Sajatovic, Martha; Gildengers, Ariel; Young, Robert C (2012) Late-life bipolar disorder: advances in treatment, conceptualization, and research methodology. J Geriatr Psychiatry Neurol 25:4-5

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