Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Modified Research Career Development Award (K04)
Project #
3K04CA000920-02S1
Application #
3071512
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1984-04-25
Project End
1989-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
O'Leary, K A; Kasper, C B (2000) Molecular basis for cell-specific regulation of the NADPH-cytochrome P450 oxidoreductase gene. Arch Biochem Biophys 379:97-108
Shen, A L; Kasper, C B (2000) Differential contributions of NADPH-cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis. J Biol Chem 275:41087-91
Huss, J M; Wang, S I; Kasper, C B (1999) Differential glucocorticoid responses of CYP3A23 and CYP3A2 are mediated by selective binding of orphan nuclear receptors. Arch Biochem Biophys 372:321-32
Shen, A L; Sem, D S; Kasper, C B (1999) Mechanistic studies on the reductive half-reaction of NADPH-cytochrome P450 oxidoreductase. J Biol Chem 274:5391-8
Huss, J M; Kasper, C B (1998) Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression. J Biol Chem 273:16155-62
Shen, A L; Kasper, C B (1996) Role of Ser457 of NADPH-cytochrome P450 oxidoreductase in catalysis and control of FAD oxidation-reduction potential. Biochemistry 35:9451-9
Huss, J M; Wang, S I; Astrom, A et al. (1996) Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc Natl Acad Sci U S A 93:4666-70
Shen, A L; Kasper, C B (1995) Role of acidic residues in the interaction of NADPH-cytochrome P450 oxidoreductase with cytochrome P450 and cytochrome c. J Biol Chem 270:27475-80
Sem, D S; Kasper, C B (1995) Effect of ionic strength on the kinetic mechanism and relative rate limitation of steps in the model NADPH-cytochrome P450 oxidoreductase reaction with cytochrome c. Biochemistry 34:12768-74
Sem, D S; Kasper, C B (1994) Kinetic mechanism for the model reaction of NADPH-cytochrome P450 oxidoreductase with cytochrome c. Biochemistry 33:12012-21

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