The long-term objectives are to improve our understanding of the pharmacology and toxicology of antitumor agents. A host of environmental substances and therapeutic agents cause pulmonary toxicity. A serious untoward effect of therapy with some antitumor agents is pulmonary toxicity. This project will examine the biochemical and cellular mechanisms responsible for anticancer drug-induced lung toxicity. Particular emphasis will be placed upon evaluating the damage caused by antitumor agents to pulmonary endothelial cell plasma membranes.
The aim of this project is to (a) characterize the biophysical and biochemical damage caused by bleomycin and other antitumor agents to the plasma membrane of pulmonary endothelium, (b) quantify the metabolism of bleomycin in various pulmonary cells and the biologic activity of novel metabolites, (c) determine if specific pulmonary cell types localize bleomycin in vivo, (d) evaluate the influence of other antitumor agents on bleomycin-induced lung toxicity and bleomycin pulmonary content and, (e) study the actions of pharmacologic agents that might reduce drug-induced lung toxicity.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Modified Research Career Development Award (K04)
Project #
5K04CA001012-05
Application #
3071587
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1987-09-01
Project End
1990-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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