Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Modified Research Career Development Award (K04)
Project #
5K04HD001076-03
Application #
2194655
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1994-06-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Temple University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Zhang, Z P; Gambone, C J; Gabriel, J L et al. (1998) Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma. J Biol Chem 273:34016-21
Scafonas, A; Wolfgang, C L; Gabriel, J L et al. (1997) Differential role of homologous positively charged amino acid residues for ligand binding in retinoic acid receptor alpha compared with retinoic acid receptor beta. J Biol Chem 272:11244-9
Wolfgang, C L; Zhang, Z; Gabriel, J L et al. (1997) Identification of sulfhydryl-modified cysteine residues in the ligand binding pocket of retinoic acid receptor beta. J Biol Chem 272:746-53
Korcz, A; Soprano, D R; Soprano, K J (1995) Tyrosine protein kinase expression in long-term quiescent WI-38 cells following growth factor simulation. J Cell Biochem 59:42-52
Soprano, D R; Soprano, K J (1995) Retinoids as teratogens. Annu Rev Nutr 15:111-32
Tairis, N; Gabriel, J L; Soprano, K J et al. (1995) Alteration in the retinoid specificity of retinoic acid receptor-beta by site-directed mutagenesis of Arg269 and Lys220. J Biol Chem 270:18380-7
Jiang, H; Soprano, D R; Li, S W et al. (1995) Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors. Int J Dev Biol 39:617-27